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P7505

Putrescine dihydrochloride

Name: Putrescine dihydrochloride
Brand: SIGMA

≥98% (TLC), powder

Synonym(s):

1,4-Butanediamine dihydrochloride, 1,4-Diaminobutane dihydrochloride, Tetramethylenediamine dihydrochloride

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About This Item

Linear Formula:

NH₂(CH₂)₄NH₂ · 2HCl

CAS Number:

333-93-7

Molecular Weight:

161.07

NACRES:

NA.77

PubChem Substance ID:

24278650

UNSPSC Code:

12352200

EC Number:

206-375-9

MDL number:

MFCD00012526

Beilstein/REAXYS Number:

3906680

Assay:

≥98% (TLC)

Form:

powder

Quality level:

400

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Product Name

Putrescine dihydrochloride, ≥98% (TLC)

Quality Level

400

assay

≥98% (TLC)

form

powder

mp

280 °C (dec.) (lit.)

solubility

H₂O: soluble 100 mg/mL, clear, colorless

SMILES string

Cl[H].Cl[H].NCCCCN

InChI

1S/C4H12N2.2ClH/c5-3-1-2-4-6;;/h1-6H2;2*1H

InChI key

XXWCODXIQWIHQN-UHFFFAOYSA-N

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Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

Putrescine dihydrochloride has been used:

as a bioactive amine standard in high-performance liquid chromatography (HPLC)
as a component of hormone mix supplemented to Dulbecco′s modified eagle medium (DMEM) to study its effects on neural stem cells
as a supplement in DMEM for culturing of endometrial cancer cells

Biochem/physiol Actions

Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine.

Binds to the polyamine modulatory site of the NMDA receptor; potentiates NMDA-induced currents.

Putrescine is an aliphatic amine and is positively charged. It acts as a precursor of spermine and plays a role in polyamine biosynthesis. Putrescine is found in several plants, animals, and bacteria. It plays a role in cell proliferation and cell growth in Escherichia coli. Putrescine is a component of agrochemicals, surfactants, pharmaceuticals, polymers, and additives.

pictograms

GHS06,GHS05

signalword

Danger

hcodes

H302,H311,H314,H330

pcodes

P260 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 1

flash_point_f

113.0 °F - closed cup

flash_point_c

45 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Alexander Disease Mutations Produce Cells with Coexpression of Glial Fibrillary Acidic Protein and NG2 in Neurosphere Cultures and Inhibit Differentiation into Mature Oligodendrocytes.

Ulises Gómez-Pinedo et al.

Frontiers in neurology, 8, 255-255 (2017-06-22)

Alexander disease (AxD) is a rare disease caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP). The disease is characterized by presence of GFAP aggregates in the cytoplasm of astrocytes and loss of myelin. Determine the effect

Vegetables consumed in Brazilian cuisine as sources of bioactive amines

Dala-Paula B M, et al.

Food Bioscience, 40, 100856-100856 (2021)

Germline modification using mouse spermatogonial stem cells.

Mito Kanatsu-Shinohara et al.

Methods in enzymology, 477, 17-36 (2010-08-12)

Spermatogonial stem cells (SSCs) in the testes are a new target for germline modification. With the development of an in vitro culture system and spermatogonial transplantation technique, SSCs can now be manipulated and used as an alternative to embryonic stem

Metabolic engineering of Escherichia coli for the production of putrescine: a four carbon diamine.

Zhi-Gang Qian et al.

Biotechnology and bioengineering, 104(4), 651-662 (2009-08-29)

A four carbon linear chain diamine, putrescine (1,4-diaminobutane), is an important platform chemical having a wide range of applications in chemical industry. Biotechnological production of putrescine from renewable feedstock is a promising alternative to the chemical synthesis that originates from

Putrescine mitigates intestinal atrophy through suppressing inflammatory response in weanling piglets.

Bangmin Liu et al.

Journal of animal science and biotechnology, 10, 69-69 (2019-09-14)

Polyamines are essential for cell growth and beneficial for intestinal maturation. To evaluate the effects of putrescine on alleviating intestinal atrophy and underlying molecular mechanisms, both in vivo feeding trial and in vitro cell culture were conducted. Weanling pigs were

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Global Trade Item Number

SKU	GTIN
P7505-25G	04061835558643
P7505-100G	04061835558636

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