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P7561

Phentolamine methanesulfonate salt

≥98% (TLC), powder

Synonym(s):

2-(N-[m-Hydroxyphenyl]-p-toluidinomethyl)imidazoline

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About This Item

Linear Formula:
C17H19N3O · CH3SO3H
CAS Number:
65-28-1
Molecular Weight:
377.46
NACRES:
NA.77
PubChem Substance ID:
24277798
UNSPSC Code:
12352116
EC Number:
200-604-6
MDL number:
MFCD00134201
Assay:
≥98% (TLC)
Form:
powder
Quality level:
200
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Quality Level

200

assay

≥98% (TLC)

form

powder

color

white to off-white

mp

180-182 °C (lit.)

solubility

ethanol: 26 mg/mL, H2O: 50 mg/mL

originator

Novartis

SMILES string

CS(O)(=O)=O.Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3

InChI

1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)

InChI key

OGIYDFVHFQEFKQ-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Biochem/physiol Actions

α-Adrenergic receptor antagonist; peripheral vasodilator.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
111H3433
043K3711
043K3710

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Jérémie Joffre et al.
Critical care medicine, 49(3), e315-e326 (2021-01-23)
Catecholaminergic vasopressors are the cornerstone of circulatory shock management. Nevertheless, catecholamines have problematic side effects, arousing a growing interest in noncatecholaminergic agents such as vasopressin or angiotensin-II. However, their respective effects on sepsis-associated microvascular endothelial dysfunction such as permeability or
Zachary Barrett-O'Keefe et al.
Clinical science (London, England : 1979), 124(6), 413-422 (2012-09-19)
Aging is characterized by increased sympatho-excitation, expressed through both the α-adrenergic and RAAS (renin-angiotensin-aldosterone) pathways. Although the independent contribution of these two pathways to elevated vasoconstriction with age may be substantial, significant cross-talk exists that could produce potentiating effects. To
Kazuhisa Honda et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 163(3-4), 260-264 (2012-08-23)
We investigated the mechanism underlying central glucagon-induced hyperglycemia and anorexia in chicks. Male 8-day-old chicks (Gallus gallus) were used in all experiments. Intracerebroventricular administration of glucagon in chicks induced hyperglycemia and anorexia from 30 min after administration. However, the plasma
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Global Trade Item Number

SKUGTIN
P7561-100MG04061832092867
P7561-500MG04061832092874