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P8624

Pirarubicin

≥95% (HPLC)

Synonym(s):

THP

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About This Item

Empirical Formula (Hill Notation):
C32H37NO12
CAS Number:
72496-41-4
Molecular Weight:
627.64
NACRES:
NA.85
PubChem Substance ID:
329820330
UNSPSC Code:
51281913
MDL number:
MFCD00869742
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Quality Segment

200

assay

≥95% (HPLC)

form

powder

solubility

ethanol: soluble 25 mg/mL

antibiotic activity spectrum

neoplastics

mode of action

DNA synthesis | interferes, enzyme | inhibits

shipped in

wet ice

storage temp.

2-8°C

SMILES string

COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](OC6CCCCO6)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO

InChI

1S/C32H37NO12/c1-14-31(45-21-8-3-4-9-42-21)17(33)10-22(43-14)44-19-12-32(40,20(35)13-34)11-16-24(19)30(39)26-25(28(16)37)27(36)15-6-5-7-18(41-2)23(15)29(26)38/h5-7,14,17,19,21-22,31,34,37,39-40H,3-4,8-13,33H2,1-2H3/t14-,17-,19-,21?,22-,31+,32-/m0/s1

InChI key

KMSKQZKKOZQFFG-NCXNULAVSA-N

Application

Pirarubicin is used to study synergistic cytotoxicity and apoptosis of cancer cells. It is used to study how to protect multi-drug resistance cells from anthracycline induced cytotoxicity.

Biochem/physiol Actions

Pirarubicin, an anthracycline antibiotic that is an analog of doxorubicin, is an antineoplastic drug. Pirarubicin is transported into cells via a sodium-dependent nucleoside transporter.1,2 It is used to intercalate DNA and inhibit the activity of topoisomerase II and induce DNA crosslinking.

Packaging

10mg,25mg

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Carc. 1B - Muta. 1B - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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