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Merck
CN

P8813

Protriptyline hydrochloride

≥99% (TLC), powder

Synonym(s):

N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H21N · HCl
CAS Number:
1225-55-4
Molecular Weight:
299.84
NACRES:
NA.77
PubChem Substance ID:
24277801
UNSPSC Code:
12352200
EC Number:
214-956-3
MDL number:
MFCD00072057

Key Documents

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InChI key

OGQDIIKRQRZXJH-UHFFFAOYSA-N

InChI

1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3;1H

SMILES string

Cl[H].CNCCCC1c2ccccc2C=Cc3ccccc13

assay

≥99% (TLC)

form

powder

color

white to off-white

solubility

H2O: 50 mg/mL

Gene Information

human ... SLC6A2(6530), SLC6A4(6532)

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Biochem/physiol Actions

Norepinephrine uptake blocker.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Disclaimer

Shelf-life of the powder is at least three years at room temperature.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLBG1302V
SLBC3353V
057K1493
082K0596
062H0436

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M M Makhay et al.
Pharmacology, biochemistry, and behavior, 63(2), 319-324 (1999-06-17)
The ability of indirectly acting agonists such as norepinephrine uptake inhibitors, serotonin reuptake inhibitors, and atypical antidepressants to substitute for clenbuterol, a beta-2 adrenergic agonist, was examined in rats trained to discriminate 0.03 mg/kg clenbuterol and saline using a fixed-ratio
G L Cohen
Headache, 37(7), 433-436 (1997-07-01)
Twenty-five women with chronic tension-type headaches were treated with protriptyline for 3 months, with attention paid to days of monthly headaches before and while taking the medication, as well as change in weight and side effects. One patient stopped the
G M Barthlen
Respiration; international review of thoracic diseases, 64 Suppl 1, 35-38 (1997-01-01)
Patients with neuromuscular disease may suffer from nocturnal respiratory failure despite normal daytime respiratory function. The physiological reduction in muscle tone during sleep may be life-threatening in a patient with impaired muscle strength. Nocturnal respiratory failure may occur in patients
P Lévy et al.
Sleep, 19(9 Suppl), S101-S110 (1996-11-01)
The spectrum of respiratory sleep disorders has been extended in the last years to include conditions that are less well defined than severe obstructive sleep apnea (OSA). Moderate OSA, snoring, and upper airway resistance syndrome (UARS) represent three conditions in
K Ström et al.
The European respiratory journal, 8(3), 425-429 (1995-03-01)
A daily dose of 20 mg of protriptyline can improve daytime arterial blood gas tensions in chronic obstructive pulmonary disease (COPD). Its usefulness is limited by anticholinergic side-effects. This study examined whether a daily dose of 10 mg of protriptyline
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