P8861
Pyrrolnitrin
from Pseudomonas cepacia, ≥98% (HPLC), antibiotic, solid
Synonym(s):
3-Chloro-4-(3-chloro-2-nitrophenyl)pyrrole
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About This Item
CAS Number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
EC Number:
213-812-7
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Product Name
Pyrrolnitrin from Pseudomonas cepacia, ≥98% (HPLC), solid
Quality Segment
assay
≥98% (HPLC)
form
solid
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
shipped in
wet ice
storage temp.
−20°C
SMILES string
[O-][N+](=O)c1c(Cl)cccc1-c2c[nH]cc2Cl
InChI
1S/C10H6Cl2N2O2/c11-8-3-1-2-6(10(8)14(15)16)7-4-13-5-9(7)12/h1-5,13H
InChI key
QJBZDBLBQWFTPZ-UHFFFAOYSA-N
Application
Pyrrolnitrin from Pseudomonas cepacia has been used as a standard in the detection of pyrrolnitrin in Serratia marcescens cell culture extract.
Biochem/physiol Actions
Pyrrolnitrin is a metabolite, produced by Pseudomonas sp.
The purified antibiotic has strong antifungal activity and is less efficient against bacteria or yeast.
Pyrrolnitrin blocks the terminal electron transport between succinate or reduced NADH and coenzyme Q. In mitochondria preparations of S. cerevisiae, the antibiotic inhibited succinate oxidase, NADH oxidase, succinate cythochrome C reductase, and NADH-cytochrome C reductase. Pyrrolnitrin is involved in many cellular processes such as oxidative stress, electron transport, DNA and RNA synthesis.
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Gloves
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