P8861
Pyrrolnitrin
from Pseudomonas cepacia, ≥98% (HPLC), antibiotic, solid
别名:
3-Chloro-4-(3-chloro-2-nitrophenyl)pyrrole
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
EC Number:
213-812-7
MDL number:
产品名称
Pyrrolnitrin from Pseudomonas cepacia, ≥98% (HPLC), solid
SMILES string
[O-][N+](=O)c1c(Cl)cccc1-c2c[nH]cc2Cl
InChI key
QJBZDBLBQWFTPZ-UHFFFAOYSA-N
InChI
1S/C10H6Cl2N2O2/c11-8-3-1-2-6(10(8)14(15)16)7-4-13-5-9(7)12/h1-5,13H
assay
≥98% (HPLC)
form
solid
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
shipped in
wet ice
storage temp.
−20°C
Quality Level
Application
Pyrrolnitrin from Pseudomonas cepacia has been used as a standard in the detection of pyrrolnitrin in Serratia marcescens cell culture extract.
Biochem/physiol Actions
The purified antibiotic has strong antifungal activity and is less efficient against bacteria or yeast.
Pyrrolnitrin is a metabolite, produced by Pseudomonas sp.
Pyrrolnitrin blocks the terminal electron transport between succinate or reduced NADH and coenzyme Q. In mitochondria preparations of S. cerevisiae, the antibiotic inhibited succinate oxidase, NADH oxidase, succinate cythochrome C reductase, and NADH-cytochrome C reductase. Pyrrolnitrin is involved in many cellular processes such as oxidative stress, electron transport, DNA and RNA synthesis.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
此项目有
Natural Antimicrobials for the Minimal Processing of Foods, 201-201 (2003)
El-Banna, N., and Winkelmann, G.
Applied Microbiology, 85, 69-69 (1998)
Magdalena M Rose et al.
Environmental microbiology, 23(9), 5525-5540 (2021-08-05)
The unicellular alga Chlamydomonas reinhardtii and the bacterium Pseudomonas protegens serve as a model to study the interactions between photosynthetic and heterotrophic microorganisms. P. protegens secretes the cyclic lipopeptide orfamide A that interferes with cytosolic Ca2+ homeostasis in C. reinhardtii
Chernin, L., et al.
Current Microbiology, 32, 208-208 (1996)
Suppression of damping-off of cucumber caused by Pythium ultimum with live cells and extracts of Serratia marcescens N4-5
Roberts DP, et al.
Soil Biology and Biochemistry, 39(9), 2275-2288 (2007)
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