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P8893

Phorbol

Name: Phorbol
Brand: SIGMA

≥98% (TLC), powder

Synonym(s):

4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₈O₆

CAS Number:

17673-25-5

Molecular Weight:

364.43

UNSPSC Code:

12352200

PubChem Substance ID:

24898990

MDL number:

MFCD00065450

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assay

≥98% (TLC)

form

powder

color

white

storage temp.

−20°C

SMILES string

C[C@@H]1[C@@H](O)[C@]2(O)[C@H]([C@@H]3C=C(CO)C[C@@]4(O)[C@@H](C=C(C)C4=O)[C@@]13O)C2(C)C

Biochem/physiol Actions

Mammary tumor promoter in experimental models.

Disclaimer

Possibly carcinogenic

pictograms

GHS06

signalword

Danger

hcodes

H300 + H310 + H330,H315,H319,H335

pcodes

P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Promotion of mammary carcinogenesis and leukemogenic action by phorbol in virgin female Wistar rats.

V Armuth et al.

Cancer research, 34(10), 2704-2707 (1974-10-01)

Brief report: Autologous stem cell transplantation restores immune tolerance in experimental arthritis by renewal and modulation of the Teff cell compartment.

Eveline M Delemarre et al.

Arthritis & rheumatology (Hoboken, N.J.), 66(2), 350-356 (2014-02-08)

Autologous stem cell transplantation (ASCT) induces long-term drug-free disease remission in patients with juvenile idiopathic arthritis. This study was undertaken to further unravel the immunologic mechanisms underlying ASCT by using a mouse model of proteoglycan-induced arthritis (PGIA). For initiation of

Interleukin-21 receptor deficiency increases the initial toll-like receptor 2 response but protects against joint pathology by reducing Th1 and Th17 cells during streptococcal cell wall arthritis.

Renoud J Marijnissen et al.

Arthritis & rheumatology (Hoboken, N.J.), 66(4), 886-895 (2014-04-24)

The cytokine interleukin-21 (IL-21) can have both proinflammatory and immunosuppressive effects. The purpose of this study was to investigate the potential dual role of IL-21 in experimental arthritis in relation to Th17 cells. Antigen-induced arthritis (AIA) and chronic streptococcal cell

Amelioration of tissue fibrosis by toll-like receptor 4 knockout in murine models of systemic sclerosis.

Takehiro Takahashi et al.

Arthritis & rheumatology (Hoboken, N.J.), 67(1), 254-265 (2014-10-11)

Bleomycin-induced fibrosis and the tight skin (TSK/+) mouse are well-established experimental murine models of human systemic sclerosis (SSc). Growing evidence has demonstrated the pivotal role of Toll-like receptors (TLRs) in several autoimmune inflammatory diseases, including SSc. This study was undertaken

Thymic stromal lymphopoietin, a novel proinflammatory mediator in rheumatoid arthritis that potently activates CD1c+ myeloid dendritic cells to attract and stimulate T cells.

Frederique M Moret et al.

Arthritis & rheumatology (Hoboken, N.J.), 66(5), 1176-1184 (2014-05-02)

To determine the levels of thymic stromal lymphopoietin (TSLP) and the numbers of TSLP receptor (TSLPR)-expressing CD1c+ (blood dendritic cell antigen 1-positive) myeloid dendritic cells (MDCs) in the joints as compared with the peripheral blood (PB) of patients with rheumatoid

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