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P8908

Prostaglandin E₁

Name: Prostaglandin E<SUB>1</SUB>
Brand: SIGMA

synthetic, powder, BioReagent, suitable for cell culture

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Synonym(s):

(11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid, Alprostadil, PGE₁

Empirical Formula (Hill Notation):

C₂₀H₃₄O₅

CAS Number:

745-65-3

Molecular Weight:

354.48

Beilstein:

5294062

EC Number:

212-017-2

MDL number:

MFCD00077860

PubChem Substance ID:

24898994

NACRES:

NA.77

biological source

synthetic

Quality Level

200

product line

BioReagent

Assay

≥98% (HPLC)

form

powder

potency

0.25-100 ng/mL

technique(s)

cell culture | mammalian: suitable

solubility

acetone: 10 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1

InChI

1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1

InChI key

GMVPRGQOIOIIMI-DWKJAMRDSA-N

Gene Information

human ... PTGER1(5731) , PTGER2(5732) , PTGIR(5739)
mouse ... Ptger1(19216) , Ptger2(19217) , Ptger3(19218) , Ptger4(19219)

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Hormones

General description

Prostaglandin E₁ (PGE1) is a vasodilator.

Application

Prostaglandin E1 may be used in cell culture to protect human umbilical vein endothelial cells (HUVEC) from injury induced by hydrogen peroxide.

Biochem/physiol Actions

Prostaglandin E₁ (PGE1) aids in the relaxation of corporal cavernosal tissue. It helps to preserve the patency of the ductus arteriosus. It is used to treat erectile dysfunction (ED).

Physical form

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Pictograms

GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Corticotrophins, corticosteroids, and prostaglandins

Side Effects of Drugs Annual, 32, 723-733 (2010)

Prostaglandin E1 for treatment of erectile dysfunction

Urciuoli R, et al.

Cochrane database of systematic reviews (Online), Cochrane(Database), Syst-Syst (2004)

Cardiac Physiology and Pharmacology

A Practice of Anesthesia for Infants and Children, 424-457 (2019)

Vasculogenic Erectile Dysfunction

Vascular Medicine: A Companion to Braunwald's Heart Disease, 341-348 (2013)

Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.

David Furman et al.

Nature medicine, 23(2), 174-184 (2017-01-17)

Low-grade, chronic inflammation has been associated with many diseases of aging, but the mechanisms responsible for producing this inflammation remain unclear. Inflammasomes can drive chronic inflammation in the context of an infectious disease or cellular stress, and they trigger the

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