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P8953

Platelet-Derived Growth Factor from porcine platelets

Name: Platelet-Derived Growth Factor from porcine platelets
Brand: SIGMA

≥97% (SDS-PAGE and N-terminal analysis), lyophilized powder, suitable for cell culture

Synonym(s):

PDGF

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00166903

Biological source:

Porcine

Assay:

≥97% (SDS-PAGE and N-terminal analysis)

Form:

lyophilized powder

Mol wt:

glycoprotein 38 kDa

Impurities:

≤1 EU/μg

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Product Name

Platelet-Derived Growth Factor from porcine platelets, PDGF, lyophilized powder, suitable for cell culture

biological source

Porcine

Quality Level

200

assay

≥97% (SDS-PAGE and N-terminal analysis)

form

lyophilized powder

potency

39.00 ng/mL EC₅₀

quality

endotoxin tested

mol wt

glycoprotein 38 kDa

packaging

pkg of 5 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

≤1 EU/μg

color

white

UniProt accession no.

P20034

storage temp.

−20°C

Gene Information

pig ... PDGFB(100626465)

Related Categories

Cell Culture & Analysis

Cell Culture Supplements & Reagents

Growth Factors and Cytokines

Molecular Biology & Functional Genomics

Application

PDGF elicits multifunctional actions with a variety of cells, including mitogenesis of mesoderm-derived cells, increased extracellular matrix synthesis, and chemotaxis and activation of neutrophils, monocytes and fibroblasts.

Biochem/physiol Actions

The principal mitogen found in mammalian serum, released from platelets during clot formation. Elicits mitogenesis of mesoderm-derived cells, increased extracellular matrix synthesis, and chemotaxis and activation of neutrophils, monocytes and fibroblasts. Mitogenic for dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells and chondrocytes. Appears to interact with transforming growth factor-β1 in accelerating wound healing. However, platelet-derived growth factor (PDGF) may also be pathogenic in arteriosclerosis and neoplasia.

Physical form

Lyophilized from a 0.2 μm filtered solution in 40% acetonitrile and 0.1% trifluoroacetic acid, pH 2.0.

Analysis Note

The mitogenic activity is tested in culture using Swiss 3T3 cells or NR6-3T3 fibroblasts.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

0000444373

0000254611

SLCP0096

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Articles

Platelet Derived Growth Factors (PDGF)

Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.

血小板衍生生长因子(PDGF)

血小板衍生生长因子是在哺乳动物血清中发现的主要有丝分裂原，在血栓形成过程中从血小板释放。

Global Trade Item Number

SKU	GTIN
P8953-5UG	04061834402114

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