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P9115

Protein Kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt

≥90% (HPLC), lyophilized powder

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About This Item

Empirical Formula (Hill Notation):
C53H98N20O12 · C2HF3O2
Molecular Weight:
1321.50
NACRES:
NA.32
PubChem Substance ID:
329820342
UNSPSC Code:
12352204
MDL number:
MFCD03788010
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Quality Level

100

assay

≥90% (HPLC)

form

lyophilized powder

solubility

H2O: soluble

storage temp.

−20°C

SMILES string

OC(=O)C(F)(F)F.CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O

InChI

1S/C53H100N20O12.C2HF3O2/c1-6-8-9-10-11-12-13-14-15-16-17-24-39(76)65-29-40(77)69-35(22-19-26-63-52(58)59)48(83)73-43(33(5)74)50(85)66-30-41(78)68-34(21-18-25-62-51(56)57)46(81)70-36(23-20-27-64-53(60)61)47(82)71-37(28-38(54)75)49(84)67-32(4)45(80)72-42(44(55)79)31(3)7-2;3-2(4,5)1(6)7/h31-37,42-43,74H,6-30H2,1-5H3,(H2,54,75)(H2,55,79)(H,65,76)(H,66,85)(H,67,84)(H,68,78)(H,69,77)(H,70,81)(H,71,82)(H,72,80)(H,73,83)(H4,56,57,62)(H4,58,59,63)(H4,60,61,64);(H,6,7)/t31-,32-,33+,34-,35-,36-,37-,42-,43-;/m0./s1

InChI key

DBHNUJXUTKVLID-UXBYPZMDSA-N

Gene Information

human ... PRKACA(5566)
mouse ... PRKACA(18747)
rat ... PRKACA(25636)

General description

Protein kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt inhibits the protein kinase cAMP-activated catalytic subunit-α (PRKACA). The gene encoding it is localized on human chromosome 19p13.1.

Application

Protein kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt has been used in cell culture for pharmaceutical inhibition and activation studies.

Biochem/physiol Actions

Cell permeable cAMP-dependent protein kinase (PKA) inhibitor
Mutations in the gene encoding protein kinase cAMP-activated catalytic subunit-α (PRKACA) have been associated with Cushing′s syndrome.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCS2257
MKCS0496
MKCS0225
MKCL9101
MKCL8612

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The gene encoding the catalytic subunit Ca of cAMP-dependent protein kinase (locus PRKACA) localizes to human chromosome region 19p13. 1
Kjetil Tasken
Genomics, 36.3 , 535-538 (1996)
The p85 regulatory subunit of PI3K mediates cAMP-PKA and insulin biological effects on MCF-7 cell growth and motility.
Di Zazzo E
TheScientificWorldJournal, 565839-565839 (2014)
Hang-Bing Dai et al.
Obesity (Silver Spring, Md.), 29(1), 86-97 (2020-09-29)
Adrenomedullin (ADM) possesses therapeutic potential for inflammatory diseases. Consequently, the effects of ADM on inflammation in visceral white adipose tissue (vWAT) of obese rats or in adipocytes were explored in this study. Male rats were fed a high-fat diet for
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Global Trade Item Number

SKUGTIN
P9115-1MG04061834402305