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P9248

PD 169316

Name: PD 169316
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₁₃FN₄O₂

CAS Number:

152121-53-4

Molecular Weight:

360.34

NACRES:

NA.77

PubChem Substance ID:

24278156

UNSPSC Code:

12352200

MDL number:

MFCD12405019

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

faint yellow to dark orange

solubility

DMSO: >10 mg/mL, H₂O: insoluble

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

[O-][N+](=O)c1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4

InChI

1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24)

InChI key

BGIYKDUASORTBB-UHFFFAOYSA-N

Gene Information

human ... MAPK14(1432)

Description

General description

PD 169316 is a pyridinyl imidazole compound. It is a potential inhibitor of p38 mitogen-activated protein kinases. It also inhibits signalling transforming growth factor β (TGFβ), particularly in human ovarian cancer cells.

Application

PD 169316 has been used for the inhibition of p38 enzyme in human hepatocytes. It has been used in culture media to promote embryoid bodies differentiation.

Biochem/physiol Actions

Potent, cell-permeable and selective p38 MAP kinase inhibitor (IC₅₀ = 89 nM).

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

GHS06,GHS05

signalword

Danger

hcodes

H301,H315,H318,H335

pcodes

P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

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The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells

Fu Y, et al.

Biochemical and Biophysical Research Communications, 310(2), 391-397 (2003)

Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons

Nath R, et al.

Cellular & Molecular Biology Letters, 6(2), 173-184 (2001)

A p38MAPK-p53 cascade regulates mesodermal differentiation and neurogenesis of embryonic stem cells

Hadjal Y, et al.

Cell Death & Disease, 4(7), e737-e737 (2013)

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Global Trade Item Number

SKU	GTIN
P9248-25MG	04061832434162
P9248-5MG	04061832434179