P9273
Pro-Phe-Arg-7-amido-4-methylcoumarin
≥95%
Synonym(s):
PFR-Nmec
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About This Item
Empirical Formula (Hill Notation):
C30H37N7O5 · C2H4O2
CAS Number:
Molecular Weight:
635.71
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
Quality Segment
assay
≥95%
form
powder
composition
Peptide content, ≥65%
solubility
methanol: 50 mg/mL, clear, colorless to faintly yellow
storage temp.
−20°C
SMILES string
NC(NCCC[C@@H](C(NC1=CC=C(C(C)=CC(O2)=O)C2=C1)=O)NC([C@H](CC3=CC=CC=C3)NC(C4NCCC4)=O)=O)=N.CC([O-])=O
InChI
1S/C30H37N7O5.ClH/c1-18-15-26(38)42-25-17-20(11-12-21(18)25)35-28(40)23(10-6-14-34-30(31)32)36-29(41)24(16-19-7-3-2-4-8-19)37-27(39)22-9-5-13-33-22;/h2-4,7-8,11-12,15,17,22-24,33H,5-6,9-10,13-14,16H2,1H3,(H,35,40)(H,36,41)(H,37,39)(H4,31,32,34);1H
InChI key
QYFPUTDFLKFOBA-UHFFFAOYSA-N
General description
A fluorogenic substrate for pancreatic and urinary kallikreins.
Application
Pro-Phe-Arg-7-amido-4-methylcoumarin has been used as fluorogenic substrate:
- in kinetic experiments to measure the enzymatic activity of factor XII
- to measure the activity of generated plasma kallikrein using Spectramax plate reader
- to determine the cathepsin A (CatA) inhibitor selectivity against various proteases using Tecan Safire 2 plate reader
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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