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P9564

Phleomycin

Name: Phleomycin
Brand: SIGMA

from Streptomyces verticillus, powder, DNA replication inhibitor

Synonym(s):

FT-0697305

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About This Item

CAS Number:

11006-33-0

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00131846

Form:

powder

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Properties

Product Name

Phleomycin from Streptomyces verticillus, powder

form

powder

Quality Segment

200

shelf life

2 yr

color

blue

antibiotic activity spectrum

fungi

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

InChI

1S/C51H75N17O21S2/c1-16-29(65-41(68-38(16)54)21(8-27(53)72)60-9-20(52)39(55)78)44(82)67-31(34(22-10-58-15-61-22)88-49-50(5,36(76)33(74)25(11-69)87-49)89-47-37(77)51(85,48(57)84)35(75)26(12-70)86-47)45(83)62-18(3)32(73)17(2)42(80)66-30(19(4)71)43(81)59-7-6-28-63-24(14-90-28)46-64-23(13-91-46)40(56)79/h10,13,15,17-18,20-21,24-26,30-37,47,49,60,69-70,73-77,85H,6-9,11-12,14,52H2,1-5H3,(H2,53,72)(H2,55,78)(H2,56,79)(H2,57,84)(H,58,61)(H,59,81)(H,62,83)(H,66,80)(H,67,82)(H2,54,65,68)/t17?,18?,20?,21?,24?,25-,26?,30?,31?,32?,33+,34?,35-,36-,37-,47-,49-,50-,51+/m0/s1

InChI key

QRBLKGHRWFGINE-UGWAGOLRSA-N

Description

General description

Phleomycin is a glycopeptide antibiotic and is a member of the bleomycin family.

Application

Phleomycin from Streptomyces verticillus has been used as an antibiotic in the screening of transformants of Trypanosoma brucei. It has also been used as an antibiotic in the maintenance of Escherichia coli.

Biochem/physiol Actions

Phleomycin can bind and intercalate with the DNA that leads to DNA strand breaks. It acts as an inhibitor of DNA replication.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number

0000543050

0000492392

0000462297

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Articles

Discover Bioactive Small Molecules for Cell Cycle

Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.

Bioactive Molecules for Apoptosis

Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.

Global Trade Item Number

SKU	GTIN
P9564-100MG	04061834403968
P9564-5MG	04061834403982
P9564-25MG	04061834403975