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Merck
CN

P9625

Phenazine methosulfate

powder, electron acceptor

Synonym(s):

5-Methylphenazinium methyl sulfate, N-Methylphenazonium methyl sulfate, PMS

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About This Item

Linear Formula:
C13H11N2 · CH3SO4
CAS Number:
299-11-6
Molecular Weight:
306.34
NACRES:
NA.77
PubChem Substance ID:
24899045
UNSPSC Code:
12352200
EC Number:
206-072-1
MDL number:
MFCD00011923
Beilstein/REAXYS Number:
3898869

Key Documents

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Product Name

Phenazine methosulfate,

InChI key

RXGJTUSBYWCRBK-UHFFFAOYSA-M

InChI

1S/C13H11N2.CH4O4S/c1-15-12-8-4-2-6-10(12)14-11-7-3-5-9-13(11)15;1-5-6(2,3)4/h2-9H,1H3;1H3,(H,2,3,4)/q+1;/p-1

SMILES string

COS([O-])(=O)=O.C[n+]1c2ccccc2nc3ccccc13

form

powder

λ

0.01 g/L in H2O, 1 cm path

UV absorption

λ: 387.5 nm Amax

antibiotic activity spectrum

fungi

mode of action

DNA synthesis | interferes
cell membrane | interferes

storage temp.

−20°C

Quality Level

200

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Application

Phenazine methosulfate is used with ascorbic acid to determine nitric oxide reductase activity.
Phenazine methosulfate has been used:
  • as a component of succinate dehydrogenase enzyme substrate solution
  • to induce superoxide radical generation in red blood cell suspensions and to study its influence on RBC deformability
  • as a component of complex II histochemistry media

Biochem/physiol Actions

Phenazine m ethosulfate (PMS) acts as a good electron acceptor. PMS is reduced non-enzymatically by (nicotinamide adenine dinucleotide) NADH and (nicotinamide adenine dinucleotide phosphate) NADPH.

General description

Phenazines are heterocyclic compounds produced as secondary metabolites by bacteria.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000504481
0000504480
0000504480
0000504481
0000463313

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Ludmila Yarmolinsky et al.
Rejuvenation research, 22(4), 282-288 (2018-10-26)
Crude ethanolic extracts from Phlomis viscosa Poiret leaves from the Judea region (Israel) are renowned for their remarkable geroprotective properties: anti-inflammatory, anti-diabetic, and anti-cancer. A phytochemical investigation carried out in this study revealed that the tested plant might belong to
Handbook on Clostridia, , pages=, 84-84 (2005)
Junji Zhang et al.
Nature communications, 8(1), 987-987 (2017-10-19)
Development of powerful fluorescence imaging probes and techniques sets the basis for the spatiotemporal tracking of cells at different physiological and pathological stages. While current imaging approaches rely on passive probe-analyte interactions, here we develop photochromic fluorescent glycoprobes capable of
Mitochondrial impairments contribute to Spinocerebellar ataxia type 1 progression and can be ameliorated by the mitochondria-targeted antioxidant MitoQ
Stucki DM, et al.
Free radical biology & medicine, 97(5-6), 427-440 (2016)
Metabolism and function of phenazines in bacteria: impacts on the behavior of bacteria in the environment and biotechnological processes
Pierson LS, et al.
Applied Microbiology and Biotechnology, 86(6), 1659-1670 (2010)
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