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Merck
CN

PLA0046

Rabbit anti-ATR Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):

FCTCS, FRAP-related protein 1, FRAP-related protein-1, FRP1, MEC1, SCKL, SCKL1, ataxia telangiectasia and Rad3 related, ataxia telangiectasia and Rad3-related protein, homolog, homolog (S. cerevisiae), mitosis entry checkpoint 1

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Rabbit anti-ATR Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.

biological source

rabbit

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

technique(s)

immunoprecipitation (IP): 2- 5 μg/mg
western blot: 1:2,000-1:10,000

accession no.

NP_001175.1

UniProt accession no.

Q13535

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

rabbit ... ATR(545)

Biochem/physiol Actions

Ataxia-telangiectasia and Rad3-related protein (ATR) plays a key role in maintaining the integrity of the genome. It participates in stabilizing replication forks and modulates the cell cycle progression and DNA repair. ATR plays a vital role in cell viability. It sends out signals to control replication origin firing, replication fork repair, and mitotic entry prematurely. Lack of ATR affects normal development, aging, and tissue homeostasis. Mutation in the ATR gene is associated with Seckel syndrome.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Ataxia telangiectasia and Rad3-related protein (ATR), a serine/threonine kinase, is a member of the phosphoinositide 3- kinase-related protein kinase s (PIKKs) family mainly to ataxia telangiectasia mutated (ATM) subfamily. It has a phosphatidylinositol 3/4 (PI3/4) kinase catalytic domain, 1 focal adhesion kinase, targeting (FAT) domain, 1 FATC domain, 1 UME domain, and 2 HEAT repeats. ATR has ATR-201 and ATR-202 isoforms. Isoform 1 is expressed at a high level in the testis. Isoform 2 is expressed in the pancreas, liver and, placenta. The ATR gene is located on human chromosome 3q23.

Immunogen

The epitope recognized by PLA0046 maps to a region between residues 1675 and 1725 of human Ataxia Telangiectasia and Rad3-related using the numbering given in entry NP_001175.1 (GeneID 545).

Other Notes

ATR (ATM and Rad3 related) is closely related to ATM (Ataxia telangiectasia, mutated) and is a member of the phosphatidylinositol 3 kinase (PI-3) family that is an early sensor of DNA damage. ATR is a serine-threonine kinase that reacts to UV damage and interruptions in replication. ATR may be able to sense DNA damage through interaction with Rad17 and 1as well as components of nucleosome remodeling complexes. In response to DNA damage, ATR has been shown to phosphorylate a multitude of substrates which include BRCA1, p53, Chk2, Rad 17, and E2F transcription factor 1.

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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1453801
Gagou ME and Meuth M
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2010)

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