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Merck
CN

PLA0083

Rabbit anti-FUS Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):

75 kDa DNA-pairing protein, ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS, amyotrophic lateral sclerosis 6, derived from t(12;16) malignant liposarcoma, fus-like protein, fused in sarcoma, fusion, fusion (involved in t(12;16) in malignant liposarcoma), fusion gene in myxoid liposarcoma, heterogeneous nuclear ribonucleoprotein P2, hnRNP-P2, oncogene FUS, oncogene TLS, translocated in liposarcoma, translocated in liposarcoma protein

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human

technique(s)

immunohistochemistry: 1:1,000-1:5,000
immunoprecipitation (IP): 2-10 μg/mg
western blot: 1:2,000-1:10,000

accession no.

P35637

UniProt accession no.

P35637

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

rabbit ... FUS(2521)

Immunogen

The epitope recognized by PLA0083 maps to a region between residues 400 and 450 of human fusion (involved in t(12;16) in malignant liposarcoma) using the numbering given in SwissProt entry P35637 (GeneID 2521).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

FUS has been identified as a frequent translocation fusion partner of various transcription factors. FUS fusion genes have been shown to be associated with multiple tumor types which include liposarcoma, leukemia, histocytoma, and sarcoma. FUS is a multifunctional RNA-binding protein that associates with the nuclear matrix and Cajal bodies and appears to play a role in splicesome assembly, pre-mRNA splicing, DNA repair, transcriptional regulation and homologous recombination.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Lot/Batch Number
5

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Tomoyasu Matsubara et al.
Neuropathology : official journal of the Japanese Society of Neuropathology, 39(1), 47-53 (2018-12-05)
Amyotrophic lateral sclerosis (ALS) primarily affects upper and lower motor neurons. Phosphorylated trans-activation response DNA-binding protein of 43 kDa (TDP-43) inclusion bodies are reportedly a pathological hallmark of sporadic ALS. Here, we present an atypical case of sporadic ALS that

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