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PLA0084

Sigma-Aldrich

Rabbit anti-FOXO1a Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):
homolog of, forkhead, in rhabdomyosarcoma, Forkhead in rhabdomyosarcoma, FKHR, forkhead box protein O1A, forkhead homolog in rhabdomyosarcoma, FOXO1A, Drosophila, FKH1
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

human

application(s)

immunoprecipitation (IP): 2-10 μg/mg
western blot: 1:2,000-1:10,000

accession no.

Q12778

shipped in

wet ice

storage temp.

2-8°C

Gene Information

rabbit ... FOXO1a(2308)

Immunogen

The epitope recognized by PLA0084 maps to a region between residues 600 and the C-terminus (residue 652) of human Forkhead Box O1a using the numbering given in Swiss-Prot entry Q12778 (GeneID 2308).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

Forkhead box protein 01A (FOXO1a) belongs to a large family of Forkhead proteins that possesses a winged-helix DNA-binding domain called Forkhead box (FOX). FOXO1 is a transcription factor that integrates cell signals to mediate metabolism, the cell cycle, DNA repair, and response to cellular stress. In response to insulin, FOXO1 is phosphorylated by Akt and excluded from the nucleus and subsequently degraded. Over-expressed cytoplasmic FOXO1 interacts with TSC2 to cause its degradation and subsequent activation of the mTOR pathway; while nuclear localization inhibits the mTOR pathway.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

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