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Merck
CN

PLA0092

Rabbit anti-MAD1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):

HsMAD1, MAD1, MAD1 (mitotic arrest deficient; yeast; homolog)-like 1, MAD1 mitotic arrest deficient-like 1, MAD1-like protein 1, PIG9, TP53I9, TXBP181, hMAD1, homolog-like 1, mitotic arrest deficient 1-like protein 1, mitotic checkpoint MAD1 protein homolog, mitotic-arrest deficient 1, tax-binding protein 181, tumor protein p53 inducible protein 9, yeast

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, IP, WB
Citations:
1

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

concentration

1 mg/mL

technique(s)

immunohistochemistry: 1:500- 1:2,000, immunoprecipitation (IP): 1-4 μg/mg, western blot: 1:5,000- 1:15,000

accession no.

Q9Y6D9

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

rabbit ... MAD1(8379)

Immunogen

The epitope recognized by PLA0092 maps to a region between residues 1 and 50 of human Mitotic arrest deficient-like 1 using the numbering given in Swiss-Prot entry Q9Y6D9 (GeneID 8379).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

MAD1 (Mitotic Arrest Deficiency 1) is a component of the mitotic spindle-assembly checkpoint that ensures that all chromosomes are aligned at the metaphase plate before the onset of anaphase. MAD1 functions as a homodimer that interacts with and regulates MAD2. MAD1 may play a role in tumor suppression.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
1

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Hirohisa Kyogoku et al.
Developmental cell, 41(3), 287-298 (2017-05-10)
Chromosome segregation during meiosis in oocytes is error prone. The uniquely large cytoplasmic size of oocytes, which provides support for embryogenesis after fertilization, might be a predisposing factor for meiotic errors. However, this hypothesis remains unproven. Here, we show that

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