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PLA0290

Sigma-Aldrich

Rabbit anti-Coilin Antibody, Affinity Purified

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Synonym(s):
p80, p80-coilin, coilin p80, CLN80

biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

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species reactivity

human

application(s)

immunohistochemistry: 1:500-1:2,000
immunoprecipitation (IP): 2- 10 μg/mg
western blot: 1:2,000- 1:10,000

accession no.

NP_004636.1

shipped in

wet ice

storage temp.

2-8°C

Gene Information

rabbit ... Coilin(8161)

Immunogen

The epitope recognized by PLA0290 maps to a region between residue 526 and 576 of human Coilin using the numbering given in entry NP_004636.1 (GeneID 8161).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

Coilin is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80 coilin [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6PJP8].

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Hande Kocak et al.
Genes & development, 28(19), 2090-2102 (2014-09-23)
Germline mutations in telomere biology genes cause dyskeratosis congenita (DC), an inherited bone marrow failure and cancer predisposition syndrome. DC is a clinically heterogeneous disorder diagnosed by the triad of dysplastic nails, abnormal skin pigmentation, and oral leukoplakia; Hoyeraal-Hreidarsson syndrome

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