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Merck
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PLA0309

Mouse anti-Rictor Monoclonal Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc., clone IG3P2C9

Synonym(s):

AVO3, AVO3 homolog, KIAA1999, MGC39830, PIA, RPTOR independent companion of MTOR, TORC2-specific protein AVO3, complex 2, hAVO3, pianissimo, rapamycin-insensitive companion of mTOR

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
IG3P2C9, monoclonal
Application:
IF, IHC, IP, WB
Citations:
2

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

IG3P2C9, monoclonal

species reactivity

human

concentration

1 mg/mL

technique(s)

immunofluorescence: 1:500-1:2,000, immunohistochemistry: 1:100- 1:500, immunoprecipitation (IP): 3 μg/mg, western blot: 1:1,000

isotype

IgG1κ

accession no.

Q6R327

UniProt accession no.

Q6R327

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... RICTOR(253260)

Immunogen

The epitope recognized by PLA0309 maps to a region between residue 1650 and the C-terminus (residue 1708) of human Rapamycin-Insensitive Companion of mTOR using the numbering given in TrEMBL entry Q6R327 (GeneID 253260).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

Rictor (rapamycin insensitive companion of TOR) is part of the rapamycin insensitive mTORC2 complex which includes mTOR, mLST8/GbetaL, Sin1, and protor 1. The mTORC2 complex appears to function in the regulation of cytoskeletal organization and has been shown to phosphorylate Akt/PKB.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
1

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Mario Palma et al.
Cell & bioscience, 13(1), 232-232 (2023-12-23)
mTORC2 is a critical regulator of cytoskeleton organization, cell proliferation, and cancer cell survival. Activated mTORC2 induces maximal activation of Akt by phosphorylation of Ser-473, but regulation of Akt activity and signaling crosstalk upon growth factor stimulation are still unclear.
Kaixuan Shi et al.
Cell death and differentiation, 30(1), 195-207 (2022-09-29)
Despite remarkable efficacy, targeted treatments often yield a subpopulation of residual tumor cells in part due to non-genetic adaptions. Previous mechanistic understanding on the emergence of these drug-tolerant persisters (DTPs) has been limited to epigenetic and transcriptional reprogramming. Here, by

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