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Merck
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PRS2447

Anti-MTBP antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 104 kDa

species reactivity

human

technique(s)

immunocytochemistry: suitable
immunofluorescence: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

Q96DY7

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MTBP(27085)

Related Categories

Immunogen

a synthetic peptide corresponding to amino acids 122-139 of human MTBP, which differ from mouse by three amino acids.

Biochem/physiol Actions

The gene MTBP (Mdm2-binding protein) is mapped to human chromosome 8q24. It is involved in the development and progression of cancer. In hepatocellular carcinoma, MTBP enhances MDM2 (E3 ubiquitin-protein ligase)-associated degradation of E-cadherin. It is also suggested as a therapeutic target for treatment of triple-negative breast cancer. MTBP is a transcriptional target of Myc. It plays an important role in cell cycle progression. Silencing of this gene causes delay in cell cycle progress at S and G2/M phases.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Other Notes

The action of this antibody can be blocked using blocking peptide SBP2447.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
24470201
2447-0201

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Assignment of the MDM2 binding protein gene (MTBP) to human chromosome band 8q24 by in situ hybridization.
Boyd MT
Cytogenetics and Cell Genetics, 90, 64-65 (2000)
MTBP Promotes the Invasion and Metastasis of Hepatocellular Carcinoma by Enhancing the MDM2-Mediated Degradation of E-Cadherin.
Lu S
Digestive Diseases and Sciences, 60, 3681-3690 (2015)
MTBP is overexpressed in triple-negative breast cancer and contributes to its growth and survival.
Grieb BC
Molecular Cancer Research, 12, 1216-1224 (2014)

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