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PRS2501

Sigma-Aldrich

Anti-CIKS antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):
Anti-TRAF3 Interacting protein 2
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 63 kDa

species reactivity

human

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

General description

CIKS (connection to IKK (IκB kinase) and SAPK (stress-activated protein kinase) /JNK (jun kinase)) is a cytoplasmic protein, that exists in the nucleus. It is also termed as Act1(NF-κB activator 1) and TRAF3IP2 (TRAF3 interacting protein 2). It is located on chromosome 6q21.

Immunogen

a synthetic peptide corresponding to amino acids 2-15 of human CIKS.

Biochem/physiol Actions

CIKS (connection to IKK (IκB kinase) and SAPK (stress-activated protein kinase) /JNK (jun kinase)) is susceptible to various diseases like psoriasis and psoriatic arthritis. It is responsible for the cardiomyocyte growth, fibroblast migration and proliferation, promoted by aldosterone. It participates in the signaling function of IL-17 (interleukin) cytokine family. It can act as a transcriptional enhancer due to its presence in the nuclear compartment of airway epithelial cells.

Linkage

The action of this antibody can be blocked using blocking peptide SBP2501.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

A Novel Nuclear Function for the Interleukin-17 Signaling Adaptor Protein Act1
Velichko S, et al.
PLoS ONE, 11(10) (2016)
Aldosterone-induced cardiomyocyte growth, and fibroblast migration and proliferation are mediated by TRAF3IP2
Somanna NK, et al.
Cellular Signalling, 27(10), 1928-1938 (2015)
Identification of alternatively spliced Act1 and implications for its roles in oncogenesis
Xia YF, et al.
Biochemical and Biophysical Research Communications, 296(2), 406-412 (2002)
A pharmacogenetics study in Mozambican patients treated with nevirapine: full resequencing of TRAF3IP2 gene shows a novel association with SJS/TEN susceptibility
Ciccacci C, et al.
International Journal of Molecular Sciences, 16(3), 5830-5838 (2015)

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