PRS3859
Anti-UNG2 (ab1) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Cyclin O, Anti-Uracil-DNA glycosylase 2
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 39 kDa
species reactivity
rat, human, mouse
technique(s)
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CCNO(10309)
General description
UNG2 (uracil-DNA glycosylase) is a multifunctional glycosylase,that is located in the nucleus. It is also known as CCNO (cyclin O)and is located on chromosome 5q11. It is present in the apical cytoplasm of multiciliated cells.
Immunogen
a 14 amino acid peptide from near the amino-terminus of human UNG2.
Biochem/physiol Actions
CCNO (cyclin O) is responsible for the differentiation of multiciliated cell. It participates in the cell cycle and DNA repair. CCNO mutations cause congenital mucociliary clearance disorder. It is considered as an important enzyme in base excision repair (BER).
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3859.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Cell cycle gene expression networks discovered using systems biology: Significance in carcinogenesis
Scott RE, et al.
Journal of Cellular Physiology, 230(10), 2533-2542 (2015)
Julia Wallmeier et al.
Nature genetics, 46(6), 646-651 (2014-04-22)
Using a whole-exome sequencing strategy, we identified recessive CCNO (encoding cyclin O) mutations in 16 individuals suffering from chronic destructive lung disease due to insufficient airway clearance. Respiratory epithelial cells showed a marked reduction in the number of multiple motile
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA
Hagen L, et al.
The Embo Journal, 27(1), 51-61 (2008)
Vpr-mediated incorporation of UNG2 into HIV-1 particles is required to modulate the virus mutation rate and for replication in macrophages
Chen R, et al.
The Journal of Biological Chemistry, 279(27), 28419-28425 (2004)
Jillian P Casey et al.
European journal of human genetics : EJHG, 23(2), 210-217 (2014-05-16)
We present a study of five children from three unrelated Irish Traveller families presenting with primary ciliary dyskinesia (PCD). As previously characterized disorders in the Irish Traveller population are caused by common homozygous mutations, we hypothesised that all three PCD
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