PRS3941
Anti-IRF7 (ab1) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Interferon regulatory factor 7
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunofluorescence
immunohistochemistry
indirect ELISA
western blot
immunohistochemistry
indirect ELISA
western blot
Species reactivity:
human, rat, mouse
Citations:
3
Technique(s):
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
Uniprot accession no.:
Product Name
Anti-IRF7 (ab1) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, rat, mouse
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... IRF7(3665)
Application
Anti-IRF7 (ab1) antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
Interferon regulatory factor 7 (IRF7) protein plays a key role in regulating the type I interferon (IFN) alpha/beta (IFNα/β) responses, which are necessary to innate and adaptive immunity. Hence IRF7 is considered as the ‘master′ controller of IFN type I production. It plays a key role in priming. IRF7 can also form homodimers or heterodimers with interferon regulatory factor 5 (IRF5) to modulate target genes. It might regulate oncogenesis and apoptosis. IRF7 plays an important role in the pathogenesis of type I diabetes. It is connected to the latency of the Epstein–Barr virus (EBV).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Interferon regulatory factor 7 (IRF7) protein, a multifunctional transcription factor, is a lymphoid-specific factor expressed in the cytoplasm in B cells, plasmacytoid dendritic cells (pDCs), and monocytes in the spleen, thymus, and peripheral blood lymphocytes. IRF7 gene is located on human chromosome 11p15.5.
Immunogen
a peptide corresponding to 14 amino acids near the carboxy-terminus of human IRF7 .
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3941.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Andrographolide inhibits chikungunya virus infection by up-regulating host innate immune pathways
Gupta S, et al.
Asian Pacific Journal of Tropical Medicine (2018)
S Ning et al.
Genes and immunity, 12(6), 399-414 (2011-04-15)
Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein-Barr virus (EBV) infection, and has since emerged as the crucial regulator of type I interferons (IFNs) against pathogenic infections, which activate IRF7 by triggering signaling cascades from
Marijana Sekulic-Jablanovic et al.
Frontiers in cellular neuroscience, 14, 566148-566148 (2020-11-17)
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