Skip to Content
Merck
CN

PRS4003

Anti-APH1 (ab2) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Anterior pharynx defective 1 homolog A (C. elegans), Anti-Presenilin stabilization factor

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Anti-APH1 (ab2) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 29 kDa

species reactivity

mouse, human, rat

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

Q96BI3

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... APH1A(51107)

Related Categories

Biochem/physiol Actions

APH1 (anterior pharynx defective-1) participates in the secretase like activity. Throughout the embryonic development, APH1 participates in presenilin dependent function.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

APH1 (anterior pharynx defective-1) is a component of γ-secretase complex. It is located on chromosome 1q21. It has 2 unique isoforms such as APH1a, located on chromosome 1 and APH1b, located on chromosome 15 (3).

Immunogen

a 18 amino acid peptide from near the center of human APH1.

Other Notes

The action of this antibody can be blocked using blocking peptide SBP4003.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Not finding the right product?  

Try our Product Selector Tool.

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
40030603
4003-0603

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Exploiting protein-protein interaction networks for genome-wide disease-gene prioritization
Guney E and Oliva B
PLoS ONE, 7(9) (2012)
Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin
Zhao G, et al.
The Journal of Neuroscience, 30(5), 1648-1656 (2010)
APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes
Pardossi-Piquard R, et al.
The Journal of Biological Chemistry, 284(24), 16298-16307 (2009)
Elisa Canepa et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association, 19(11), 5048-5073 (2023-05-15)
Cerebrovascular pathology is an early and causal hallmark of Alzheimer's disease (AD), in need of effective therapies. Based on the success of our previous in vitro studies, we tested for the first time in a model of AD and cerebral

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service