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PRS4101

Sigma-Aldrich

Anti-Neuritin antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):
Anti-NRN1, Anti-Cpg15, Anti-Neuritin 1

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 16 kDa

species reactivity

human, mouse

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... NRN1(51299)

General description

Neuritin (NRN1) is a candidate plasticity associated gene, that is a member of the neurotrophic factor family. It is also known as CPG15. It is expressed in the liver, heart, lungs, skeletal muscle and other normal organs along with the nervous system. It is also expressed in gastric cancer tissues. It is mapped to chromosome 6p24-p2.

Immunogen

a 20 amino acid peptide from near the center of human neuritin.

Application

Anti-Neuritin has been used in immunohistochemistry and western blotting.

Biochem/physiol Actions

In gastric cancer treatment, neuritin (NRN1) serves as a potential target. It also participates in the pathogenesis of tumors. It plays a major role in the nervous system and on the migration, senescence, proliferation, and viability of stem cells.

Linkage

The action of this antibody can be blocked using blocking peptide SBP4101.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Ming Yuan et al.
Oncology letters, 10(6), 3832-3836 (2016-01-21)
The aim of the present study was to investigate the expression of neuritin in gastric cancer tissues, in order to explore the association between the expression of neuritin and the occurrence and development of gastric cancer. Tissue specimens were collected
Impact of Neuritin 1 (NRN1) polymorphisms on fluid intelligence in schizophrenia
Chandler D, et al.
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 153B(2), 428-437 (2010)
Overexpression of neuritin in gastric cancer
Yuan M, et al.
Oncology Letters, 10(6), 3832-3836 (2015)
Shuhei Kamada et al.
Frontiers in oncology, 11, 758503-758503 (2021-11-23)
Acquired therapeutic resistance and metastasis/recurrence remain significant challenge in advance renal cell carcinoma (RCC), thus the establishment of patient-derived cancer models may provide a clue to assess the problem. We recently characterized that neuritogenesis-related protein neuritin 1 (NRN1) functions as
Effects of neuritin on the migration, senescence and proliferation of human bone marrow mesenchymal stem cells
Wang X, et al.
Cellular & Molecular Biology Letters, 20(3), 466-474 (2015)

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