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Merck
CN

PRS4237

Anti-Op18 (ab2) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-LAP18, Anti-Lag, Anti-Oncoprotein 18, Anti-STMN1, Anti-Stathmin 1

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About This Item

NACRES:
NA.43
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IF, IHC, WB
Citations:
3

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse, rat

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

UniProt accession no.

P16949

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... STMN1(3925)

General description

Op18 (oncoprotein 18) is a cytoplasmic phosphoprotein, that is of 17kDa. It is also termed as stathmin1 (STMN1). It is partially found in the nucleus of all tumor tissues. It is located on chromosome 1p36.1.

Immunogen

a 17 amino acid peptide from near the amino-terminus of human op18.

Biochem/physiol Actions

Op18 (oncoprotein 18) plays a major role in the multiplication and migration of hypopharyngeal squamous cell carcinoma (HSCC), hence it can be considered as a therapeutic target of HSCC. It participates in the reconstitution of microtubule cytoskeleton, cell cycle progression and cell migration. Silencing STMN1 may affect the cell cycle progression, apoptosis, metastasis and chemoresistance of tumor cells.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Other Notes

The action of this antibody can be blocked using blocking peptide SBP4237.

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
42370702
4237-0702

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Stathmin1 overexpression in hypopharyngeal squamous cell carcinoma: A new promoter in FaDu cell proliferation and migration
Chen Y, et al.
International Journal of Oncology, 50(1), 31-40 (2017)
A cohort study of STMN1 expression in colorectal cancer: body mass index and prognosis
Ogino S, et al.
The American Journal of Gastroenterology, 104(8), 2047-2056 (2009)
Comparison between osteoblasts derived from human dental pulp stem cells and osteosarcoma cell lines
Palmieri A, et al.
Cell Biology International, 32(7), 733-738 (2008)

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