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Merck
CN

PVP1

Poly(vinylpyrrolidone)–Iodine complex

Synonym(s):

PVP-Iodine, Polyvinylpyrrolidone Iodine, PVP-I, Povadyne® antiseptic

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About This Item

CAS Number:
25655-41-8
NACRES:
NA.85
PubChem Substance ID:
24899316
UNSPSC Code:
51102829
MDL number:
MFCD00084483

Key Documents

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InChI

1S/C6H9NO.I2/c1-2-7-5-3-4-6(7)8;1-2/h2H,1,3-5H2;

SMILES string

II.C=CN1CCCC1=O

InChI key

CPKVUHPKYQGHMW-UHFFFAOYSA-N

form

powder

solubility

H2O: 100 mg/mL

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, fungi, parasites, viruses, yeast

mode of action

protein synthesis | interferes

Quality Level

200

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Application

Poly(vinylpyrrolidone)–Iodine complex, or PVP-I, has been used to study microbial decontamination of human donor eyes and the inactivation of infectious hematopoietic necrosis virus.

Biochem/physiol Actions

PVP-1 is used as a slow iodine release formulation that iodinates lipids and oxidizes cell compounds such as tyrosine sidechains. It is used as a carbon nanotube coating agent to improve water solubility.

Other Notes

An iodophor; "tamed iodine."
Keep container tightly closed in a dry and well-ventilated place.

Legal Information

Povadyne is a registered trademark of National Patent Development Corp.

pictograms

CorrosionEnvironment
GHS05,GHS09

signalword

Danger

Hazard Classifications

Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

>212.0 °F - Not applicable

flash_point_c

> 100 °C - Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000431487
0000431486
0000431486
0000431487
0000423024

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Yangzi Jiang et al.
Acta biomaterialia, 9(9), 8089-8098 (2013-05-28)
Polyvinylpyrrolidone-iodine (Povidone-iodine, PVP-I) is widely used as an antiseptic agent for lavation during joint surgery; however, the biological effects of PVP-I on cells from joint tissue are unknown. This study examined the biocompatibility and biological effects of PVP-I on cells
Usa Boonyuen et al.
Analytica chimica acta, 1122, 61-69 (2020-06-07)
Recently, several studies have examined possible applications of nanoparticles for the development of electronic and optical sensors. The plasmon absorbance of gold nanoparticles has been used extensively to study biomolecular processes, including nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate-dependent enzymatic reactions.
Karen Pawlowski et al.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 34(1), 167-174 (2012-12-04)
Repeated applications of low-concentration povidone iodine (PI) combined with dexamethasone (Dex) through a tympanic membrane ventilation tube will not cause ototoxic changes in the rat. Otitis externa (OE) and acute otitis media (AOM) are 2 of the most common otologic
X X Hao et al.
Poultry science, 92(10), 2560-2566 (2013-09-21)
Lots of microorganisms exist in layer houses can cause bird diseases and worker health concerns. Spraying chemical disinfectants is an effective way to decontaminate pathogenic microorganisms in the air and on surfaces in poultry houses. Slightly acidic electrolyzed water (SAEW
Jo C Dumville et al.
The Cochrane database of systematic reviews, 3(3), CD003949-CD003949 (2013-04-02)
Surgical site infection rates in the month following clean surgery vary from 0.6% (knee prosthesis) to 5% (limb amputation). Due to the large number of clean surgical procedures conducted annually the costs of these surgical site infections (SSIs) can be
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