Name: Maraviroc
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₂₉H₄₁F₂N₅O

CAS Number:

376348-65-1

Molecular Weight:

513.67

MDL number:

MFCD13188530

UNSPSC Code:

12352200

PubChem Substance ID:

329823671

NACRES:

NA.77

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Assay

≥98% (HPLC)

form

powder

optical activity

[α]-15/D

color

white

solubility

DMSO: >30 mg/mL

storage temp.

room temp

SMILES string

CC(C)c1nnc(C)n1[C@H]2C[C@@H]3CC[C@H](C2)N3CC[C@H](NC(=O)C4CCC(F)(F)CC4)c5ccccc5

InChI

1S/C29H41F2N5O/c1-19(2)27-34-33-20(3)36(27)25-17-23-9-10-24(18-25)35(23)16-13-26(21-7-5-4-6-8-21)32-28(37)22-11-14-29(30,31)15-12-22/h4-8,19,22-26H,9-18H2,1-3H3,(H,32,37)/t23-,24+,25-,26-/m0/s1

InChI key

GSNHKUDZZFZSJB-QYOOZWMWSA-N

Gene Information

human ... CCR5(1234)

Related Categories

Bioactive Small Molecules

Application

Maraviroc has been used as a C-C chemokine receptor type 5 (CCR5-specific) inhibitor in murine monocyte/macrophage cell line J774A.1, porcine uterine luminal epithelial cells and human lung CD4⁺ T cells.

Biochem/physiol Actions

Maraviroc is a CCR5 chemokine receptor antagonist and antiretroviral entry inhibitor.

Maraviroc is a CCR5 chemokine receptor antagonist, and antiretroviral entry inhibitor. Maraviroc inhibits HIV entry by blocking interaction of viral coat protein gp120 with the receptor.

Maraviroc is metabolised by cytochrome P450 3A4. The transport and absorption of maraviroc in the intestine and bile is regulated by P-glycoprotein (Pgp). Maraviroc binds to the active site pocket of chemokine receptor CCR5 making the receptor inactive.

Features and Benefits

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000389462

0000231530

0000055201

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