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PZ0012

Sunitinib malate

Name: Sunitinib malate
Brand: SIGMA

≥98% (HPLC), powder, receptor tyrosine kinase inhibitor

Synonym(s):

N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioic acid (1:1) salt, SU 011248, SU 11248, SU112248

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₇FN₄O₂ · C₄H₆O₅

CAS Number:

341031-54-7

Molecular Weight:

532.56

UNSPSC Code:

12352200

PubChem Substance ID:

329823681

NACRES:

NA.77

MDL number:

MFCD08282795

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Properties

Product Name

Sunitinib malate, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

solubility

DMSO: >10 mg/mL

storage temp.

room temp

SMILES string

O[C@@H](CC(O)=O)C(O)=O.CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C

InChI

1S/C22H27FN4O2.C4H6O5/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28;5-2(4(8)9)1-3(6)7/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28);2,5H,1H2,(H,6,7)(H,8,9)/b17-12-;/t;2-/m.0/s1

InChI key

LBWFXVZLPYTWQI-IPOVEDGCSA-N

Gene Information

human ... CSF1R(1436), FLT1(2321), FLT3(2322), FLT4(2324), KDR(3791), KIT(3815), PDGFRA(5156), PDGFRB(5159), RET(5979)

Description

Application

Sunitinib malate has been used:

to study its mechanism in the inhibition of MCF-7 cell migration and angiogenesis
as a reference molecule to compare its docking energies with other ligands/vascular endothelial growth factor receptor (VEGF) receptor blocker
used in proliferation assay

Biochem/physiol Actions

Sunitinib has greater bioavailability and potency compared to other inhibitors. It prevents angiogenesis.

Sunitinib malate is a receptor tyrosine kinase inhibitor, which targets VEGF-R1, VEGF-R2, VEGF-R3, PDGF-Rα, PDGF-Rβ, KIT, FLT3, CSF-1R, and RET. Sunitinib malate is an anticancer drug.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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pictograms

GHS08

signalword

Danger

hcodes

H360,H372

pcodes

P202 - P260 - P264 - P280 - P308 + P313 - P405

Hazard Classifications

Repr. 1B - STOT RE 1 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Articles

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy.

Iris Uribesalgo et al.

EMBO molecular medicine, 11(8), e9266-e9266 (2019-07-04)

Angiogenesis is a hallmark of cancer, promoting growth and metastasis. Anti-angiogenic treatment has limited efficacy due to therapy-induced blood vessel alterations, often followed by local hypoxia, tumor adaptation, progression, and metastasis. It is therefore paramount to overcome therapy-induced resistance. We

Sunitinib: from rational design to clinical efficacy

Chow LQM and Eckhardt SG

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 25(7), 884-896 (2007)

Orthogonal Drug Pooling Enhances Phenotype-Based Discovery of Ocular Antiangiogenic Drugs in Zebrafish Larvae.

Nils Ohnesorge et al.

Frontiers in pharmacology, 10, 508-508 (2019-06-11)

Unbiased screening of large randomized chemical libraries in vivo is a powerful tool to find new drugs and targets. However, forward chemical screens in zebrafish can be time consuming and usually >99% of test compounds have no significant effect on

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Global Trade Item Number

SKU	GTIN
PZ0012-5MG	04061836687342
PZ0012-25MG	04061836687335