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PZ0015

Trovafloxacin mesylate

>98% (HPLC), powder, Pannexin 1 inhibitor

Synonym(s):

(1α,5α,6α)-7-(6-Amino-3-azabicyclo[3.1.0]hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid methanesulfonate, CP-99219-27, Trovafloxacin methanesulfonate

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About This Item

Empirical Formula (Hill Notation):
C20H15F3N4O3 · CH3SO3H
CAS Number:
147059-75-4
Molecular Weight:
512.46
UNSPSC Code:
12352200
PubChem Substance ID:
329823684
NACRES:
NA.77
MDL number:
MFCD00913361
Assay:
>98% (HPLC)
Form:
powder
Quality level:
100
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Product Name

Trovafloxacin mesylate, >98% (HPLC)

Quality Level

100

assay

>98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >10 mg/mL

storage temp.

room temp

SMILES string

CS(O)(=O)=O.NC1C2CN(CC12)c3nc4N(C=C(C(O)=O)C(=O)c4cc3F)c5ccc(F)cc5F

InChI

1S/C20H15F3N4O3.CH4O3S/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24;1-5(2,3)4/h1-4,7,10-11,16H,5-6,24H2,(H,29,30);1H3,(H,2,3,4)/t10-,11+,16+;

InChI key

DYNZICQDCVYXFW-AHZSKCOESA-N

Application

Trovafloxacin mesylate has been used as a test compound in toxicity assay to assess its toxicity in 2D hepatocyte cultures. It has also been used to manipulate the mechanism of apoptotic cell disassembly during apoptosis.

Biochem/physiol Actions

Trovafloxacin mesylate acts as a pannexin1 (Panx1) inhibitor.
Trovafloxacin mesylate is a broad spectrum antibiotic.
Trovafloxacin mesylate is a broad spectrum antibiotic. Trovafloxacin mesylate blocks the activity of DNA gyrase and topoisomerase IV, enzymes essential in the repliction, transcription, and repair of bacterial DNA.

pictograms

Health hazardCorrosion
GHS08,GHS05

signalword

Danger

hcodes

H314,H361

Hazard Classifications

Repr. 2 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
020M4708V
020M47081
020M4708

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Articles

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Determining the contents and cell origins of apoptotic bodies by flow cytometry
Jiang L, et al.
Scientific reports, 7(1), 14444-14444 (2017)
Bioprinted 3D primary liver tissues allow assessment of organ-level response to clinical drug induced toxicity in vitro
Nguyen DG, et al.
PLoS ONE, 11(7), e0158674-e0158674 (2016)
Akira Nakajima et al.
Cell biology and toxicology, 34(1), 65-77 (2017-03-13)
Fluoroquinolones and propionic acid derivatives are widely used antibacterials and non-steroidal anti-inflammatory drugs, respectively, which have been reported to frequently trigger drug hypersensitivity reactions. Such reactions are induced by inflammatory mediators such as cytokines and chemokines. The present study investigated
View All Related Papers

Global Trade Item Number

SKUGTIN
PZ0015-5MG04061832632445
PZ0015-25MG04061832632438