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Merck
CN

PZ0111

PD-407824

≥98% (HPLC)

Synonym(s):

9-Hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione

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About This Item

Empirical Formula (Hill Notation):
C20H12N2O3
CAS Number:
622864-54-4
Molecular Weight:
328.32
NACRES:
NA.77
PubChem Substance ID:
329823703
UNSPSC Code:
12352200
MDL number:
MFCD09753286

Key Documents

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Product Name

PD-407824, ≥98% (HPLC)

InChI

1S/C20H12N2O3/c23-11-6-7-14-13(8-11)16-15(21-14)9-12(10-4-2-1-3-5-10)17-18(16)20(25)22-19(17)24/h1-9,21,23H,(H,22,24,25)

SMILES string

Oc1ccc2[nH]c3cc(-c4ccccc4)c5C(=O)NC(=O)c5c3c2c1

InChI key

IAUZTOZLTFSMIE-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

yellow to orange

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

Quality Level

100

Application

PD-407824 has been used as a wee-1 inhibitor to study its effects on Xenopus laevis embryos. It has also been used as a checkpoint-1 (Chk-1) inhibitor to study its effects on the sensitivity of head and neck squamous carcinoma cells to gemcitabine.

Biochem/physiol Actions

PD-407824 is a Wee1/Chk1 inhibitor.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
010M4740V
010M4740V
010M4740

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Gemcitabine Inhibits Murine Head and Neck Squamous Cell Carcinoma Growth via Proteasome-Dependent Degradation of Chk1 Leading to Cell Cycle Arrest and Apoptosis
Song A, et al.
Journal of Cancer Therapy (2012)
Allyson E Kennedy et al.
Developmental biology, 365(1), 229-240 (2012-03-13)
The upper lip and primary palate form an essential separation between the brain, nasal structures and the oral cavity. Surprisingly little is known about the development of these structures, despite the fact that abnormalities can result in various forms of
Rui Zu et al.
Cell death & disease, 12(11), 994-994 (2021-10-25)
Necroptosis is a form of regulated necrotic cell death that promotes inflammation. In cells undergoing necroptosis, activated RIPK1 kinase mediates the formation of RIPK1/RIPK3/MLKL complex to promote MLKL oligomerization and execution of necroptosis. RIPK1 kinase activity also promotes cell-autonomous activation

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