PZ0111
PD-407824
≥98% (HPLC)
别名:
9-Hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
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关于此项目
经验公式（希尔记法）:
C20H12N2O3
化学文摘社编号:
分子量:
328.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
PD-407824, ≥98% (HPLC)
InChI
1S/C20H12N2O3/c23-11-6-7-14-13(8-11)16-15(21-14)9-12(10-4-2-1-3-5-10)17-18(16)20(25)22-19(17)24/h1-9,21,23H,(H,22,24,25)
SMILES string
Oc1ccc2[nH]c3cc(-c4ccccc4)c5C(=O)NC(=O)c5c3c2c1
InChI key
IAUZTOZLTFSMIE-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
yellow to orange
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
Quality Level
Application
PD-407824 has been used as a wee-1 inhibitor to study its effects on Xenopus laevis embryos. It has also been used as a checkpoint-1 (Chk-1) inhibitor to study its effects on the sensitivity of head and neck squamous carcinoma cells to gemcitabine.
Biochem/physiol Actions
PD-407824 is a Wee1/Chk1 inhibitor.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Gemcitabine Inhibits Murine Head and Neck Squamous Cell Carcinoma Growth via Proteasome-Dependent Degradation of Chk1 Leading to Cell Cycle Arrest and Apoptosis
Song A, et al.
Journal of Cancer Therapy (2012)
Allyson E Kennedy et al.
Developmental biology, 365(1), 229-240 (2012-03-13)
The upper lip and primary palate form an essential separation between the brain, nasal structures and the oral cavity. Surprisingly little is known about the development of these structures, despite the fact that abnormalities can result in various forms of
Rui Zu et al.
Cell death & disease, 12(11), 994-994 (2021-10-25)
Necroptosis is a form of regulated necrotic cell death that promotes inflammation. In cells undergoing necroptosis, activated RIPK1 kinase mediates the formation of RIPK1/RIPK3/MLKL complex to promote MLKL oligomerization and execution of necroptosis. RIPK1 kinase activity also promotes cell-autonomous activation
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