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PZ0115

CP-31398 dihydrochloride hydrate

≥98% (HPLC)

Synonym(s):

N′-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine dihydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):
C22H26N4O·2HCl · xH2O
Molecular Weight:
435.39 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
329823707
UNSPSC Code:
12352200
MDL number:
MFCD17215956
Assay:
≥98% (HPLC)
Storage condition:
desiccated
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Quality Segment

100

assay

≥98% (HPLC)

storage condition

desiccated

color

yellow

solubility

H2O: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

O.Cl.Cl.COc1ccc(cc1)\C=C\c2nc(NCCCN(C)C)c3ccccc3n2

InChI

1S/C22H26N4O.2ClH.H2O/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17;;;/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25);2*1H;1H2/b14-11+;;;

InChI key

JXIVIAMOMIONKY-UWCBQFGESA-N

Gene Information

human ... TP53(7157)
mouse ... TP53(22059)
rat ... TP53(24842)

Application

CP-31398 dihydrochloride hydrate has been used as a p53 stabilizer:
  • to evaluate its effects on the upregulation of miRNA in human neuroblastoma cells
  • to study its effects on arsenic trioxide (ATO) stabilization of p53 folding
  • to study its effects on regulation of miR-34 in PC12 cells

Biochem/physiol Actions

CP-31398 is a styryl quinazoline that functions in preserving the activity of p53 as a tumor suppressor and transcription factor. The DNA-binding activity and apoptosis functionality of the p53 are restored by CP-31398. CP-31398 exhibits therapeutic effects against liver, skin, pancreatic, and colon cancers.
CP-31398 dihyrochloride hydrate is a p53 stabilizer; apoptosis inducer.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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