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PZ0115

CP-31398 dihydrochloride hydrate

≥98% (HPLC)

Synonym(s):

N′-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine dihydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):
C22H26N4O·2HCl · xH2O
Molecular Weight:
435.39 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
329823707
UNSPSC Code:
12352200
MDL number:
MFCD17215956
Assay:
≥98% (HPLC)
Quality level:
100
Storage condition:
desiccated
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Quality Level

100

assay

≥98% (HPLC)

storage condition

desiccated

color

yellow

solubility

H2O: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

O.Cl.Cl.COc1ccc(cc1)\C=C\c2nc(NCCCN(C)C)c3ccccc3n2

InChI

1S/C22H26N4O.2ClH.H2O/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17;;;/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25);2*1H;1H2/b14-11+;;;

InChI key

JXIVIAMOMIONKY-UWCBQFGESA-N

Gene Information

human ... TP53(7157)
mouse ... TP53(22059)
rat ... TP53(24842)

Application

CP-31398 dihydrochloride hydrate has been used as a p53 stabilizer:
  • to evaluate its effects on the upregulation of miRNA in human neuroblastoma cells
  • to study its effects on arsenic trioxide (ATO) stabilization of p53 folding
  • to study its effects on regulation of miR-34 in PC12 cells

Biochem/physiol Actions

CP-31398 dihyrochloride hydrate is a p53 stabilizer; apoptosis inducer.
CP-31398 is a styryl quinazoline that functions in preserving the activity of p53 as a tumor suppressor and transcription factor. The DNA-binding activity and apoptosis functionality of the p53 are restored by CP-31398. CP-31398 exhibits therapeutic effects against liver, skin, pancreatic, and colon cancers.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000187059
0000187058
0000182682
050M4609V
0000182682

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Articles

Discover Bioactive Small Molecules for Cell Cycle

Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.

Bioactive Molecules for Apoptosis

Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.

William D Johnson et al.
Toxicology, 289(2-3), 141-150 (2011-08-26)
CP-31398 (N'-[2-[2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine dihydrochloride) is a styrylquinazoline that stabilizes the DNA binding conformation of p53, thereby maintaining the activity of p53 as a transcription factor and tumor suppressor. In consideration of the potential use of p53 stabilizers for cancer prevention and
Ling Liu et al.
International journal of oncology, 54(3), 942-954 (2019-01-11)
Endometrial cancer (EC) is one of the most common malignancies of the female reproductive system, and metastasis is a major cause of mortality. In this study, we aimed to explore the role of CP‑31398 in the migration, invasion and apoptosis
Abhishek Jauhari et al.
Molecular neurobiology, 55(2), 936-945 (2017-01-14)
Differentiation of neural stem cells (NSC's) to mature and functional neurons requires coordinated expression of mRNA, microRNAs (miRNAs) and regulatory proteins. Our earlier unbiased miRNA profiling studies have identified miR-200, miR-34 and miR-221/222 as maximally up-regulated miRNA families in differentiating
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Global Trade Item Number

SKUGTIN
PZ0115-25MG04061832925264
PZ0115-5MG04061836687410