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PZ0116

PD-166285 hydrate

≥98% (HPLC)

Synonym(s):

6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):
C26H27Cl2N5O2·2HCl
Molecular Weight:
585.35
NACRES:
NA.77
PubChem Substance ID:
329823708
UNSPSC Code:
51111800
MDL number:
MFCD17215957
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

yellow

solubility

DMSO: ≥20 mg/mL, H2O: ≥5 mg/mL

storage temp.

room temp

SMILES string

O.Cl.Cl.CCN(CC)CCOc1ccc(Nc2ncc3C=C(C(=O)N(C)c3n2)c4c(Cl)cccc4Cl)cc1

InChI

1S/C26H27Cl2N5O2.2ClH.H2O/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28;;;/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31);2*1H;1H2

InChI key

FHIIMEXCWLFXBU-UHFFFAOYSA-N

Application

PD-166285 Hydrate has been used as a fibroblast growth factor (FGF) signaling inhibitor to study its effects on LIM-homeodomain gene 9 (Lhx9) expression during limb development in mice.

Biochem/physiol Actions

PD-166285 is also a potent inhibitor of Wee-1, epidermal growth factor receptor, and platelet-derived growth factor receptor β subunit (PDGFR-β). It also exhibits its inhibitory effects against mitogen-activated protein kinase (MAPK) and protein kinase C (PKC). PD-166285 shows antiproliferative and anti-migratory effects due to which it may be used as a therapeutic agent against atherosclerosis, restenosis, and cancer.
PD-166285 hydrate is a broad spectrum protein tyrosine kinase inhibitor; Src and FGFR kinase inhibitor.

Features and Benefits

This compound is featured on the FGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Codes

H301,H413

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 4

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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