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Merck
CN

PZ0129

CP-380736

≥98% (HPLC)

Synonym(s):

6,7-Bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one, 6,7-Bis(2-methoxyethoxy)-4(3H)-quinazolinone, PF-00520893

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About This Item

Empirical Formula (Hill Notation):
C14H18N2O5
CAS Number:
179688-29-0
Molecular Weight:
294.30
NACRES:
NA.77
PubChem Substance ID:
329823716
UNSPSC Code:
51111800
MDL number:
MFCD02678087

Key Documents

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Product Name

CP-380736, ≥98% (HPLC)

InChI key

PMQWTUWLIGJTQD-UHFFFAOYSA-N

SMILES string

COCCOc1cc2N=CNC(=O)c2cc1OCCOC

InChI

1S/C14H18N2O5/c1-18-3-5-20-12-7-10-11(15-9-16-14(10)17)8-13(12)21-6-4-19-2/h7-9H,3-6H2,1-2H3,(H,15,16,17)

assay

≥98% (HPLC)

form

powder

color

off-white to light tan

solubility

DMSO: ≥10 mg/mL

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

CP-380736 is an inhibitor of the epidermal growth factor receptor (EGFR). EGFR is a tyrosine kinase that activates MAPK, JNK, and Akt pathways, and is an important mediator of several types of cancer, including lung cancer and glioblastoma multiforme.
CP-380736 is selective inhibitor of epidermal growth factor receptor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
060M4715V
060M4715

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Belén Sánchez-Maldonado et al.
Stem cells and development, 27(22), 1557-1576 (2018-09-27)
Cell spheroids are inducible or spontaneously generated cell aggregates produced in vitro that can provide a valuable model for developmental biology, stem cell biology, and cancer therapy research. This investigation aimed to define the cellular identity of spheroids spontaneously generated

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