PZ0147
PHA-665752 hydrate
≥98% (HPLC)
Synonym(s):
(3Z)-5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[(2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one hydrate
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About This Item
Quality Segment
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +50 to +70°, c = 0.2 in methanol
color
light yellow to light brown
solubility
DMSO: ≥20 mg/mL
storage temp.
2-8°C
SMILES string
O.Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc4c(Cl)cccc4Cl)c(C)c1C(=O)N5CCC[C@@H]5CN6CCCC6
InChI
1S/C32H34Cl2N4O4S.H2O/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34;/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39);1H2/b24-16-;/t21-;/m1./s1
InChI key
MKHQWLQMOSOUEQ-SCLITUASSA-N
Application
- to study its effects on oxidative stress in human mammary epithelial MCF10A cells with extra centrosomes
- to study its effects on the clonogenicity of T-cell specific transcription factor/ lymphoid enhancer-binding factor-1 (TCF/LEF-1) responsive promoter to drive expression of green fluorescent protein (TOP-GFP) cancer stem cell (CSC) cultures
- to study its inhibitory effects on melanoma cell lines
Biochem/physiol Actions
Features and Benefits
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
Global Trade Item Number
| SKU | GTIN |
|---|---|
| PZ0147-25MG | 04061832962467 |
| PZ0147-5MG | 04061836687434 |