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Merck
CN

PZ0158

PF 3845 hydrate

≥98% (HPLC)

Synonym(s):

N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide hydrate

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About This Item

Empirical Formula (Hill Notation):
C24H23F3N4O2 · xH2O
CAS Number:
1196109-52-0
Molecular Weight:
456.46 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
329823740
UNSPSC Code:
51111800
MDL number:
MFCD21365072
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

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InChI

1S/C24H23F3N4O2.H2O/c25-24(26,27)19-6-7-22(29-15-19)33-21-5-1-3-18(14-21)13-17-8-11-31(12-9-17)23(32)30-20-4-2-10-28-16-20;/h1-7,10,14-17H,8-9,11-13H2,(H,30,32);1H2

SMILES string

O.FC(F)(F)c1ccc(Oc2cccc(CC3CCN(CC3)C(=O)Nc4cccnc4)c2)nc1

InChI key

CVQMBUCCSAKASE-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

DMSO: ≥45 mg/mL

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

PF 3845 hydrate is a potent, irreversible FAAH inhibitor
PF 3845 is a potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. The endocannabinoid system is a target for therapeutic pain relief. PF-3845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It high selectivity over other enzymes including FAAH-2. In mouse studies, PF-3845 has been shown to raise brain anandamide levels for up to 24 hr; and in a rat model it produced significant reduction of inflammatory pain..

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000446327
0000446327
0000401448
0000144964
101M4706V

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