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PZ0160

UK-5099

Name: UK-5099
Brand: SIGMA

≥98% (HPLC), powder, mitochondrial pyruvate carrier inhibitor

Synonym(s):

2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, PF-1005023

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₁₂N₂O₂

CAS Number:

56396-35-1

Molecular Weight:

288.30

UNSPSC Code:

12352200

PubChem Substance ID:

329823742

NACRES:

NA.77

MDL number:

MFCD19443867

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Product Name

UK-5099, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

color

yellow to tan

solubility

DMSO: >20 mg/mL

storage temp.

2-8°C

SMILES string

OC(=O)\C(=C\c1cn(-c2ccccc2)c3ccccc13)C#N

InChI

1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+

InChI key

BIZNHCWFGNKBBZ-JLHYYAGUSA-N

Description

Application

UK-5099 has been used:

as a mitochondrial pyruvate blocker to reduce pyruvate transportation into mitochondria in Roswell park memorial institute (RPMI) 1640 medium for prostatic cancer cell line culture
in dimethyl sulfoxide (DMSO) stock, to study the effect of inhibiting pyruvate transport into mitochondria on pro-inflammatory responses in lipopolysaccharide activated macrophages
in topical treatment in order to study its effect on hair cycle induction in experimental mice

Biochem/physiol Actions

UK-5099 induces lactate generation.

UK-5099 is a potent inhibitor of the mitochondrial pyruvate transporter.

UK-5099 is a potent inhibitor of the mitochondrial pyruvate transporter. In rat heart mitochondria, UK-5099 inhibits pyruvate-dependent O₂ consumption with an IC₅₀ of 50 nM.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c