PZ0176
SC-26196
≥98% (HPLC)
别名:
SC-26196, a,a-diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile; 2,2-diphenyl-5-(4-[[(1 E)-pyridin-3-yl-methylidene]amino]piperazin-1-yl)pentanenitrile
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关于此项目
经验公式（希尔记法）:
C27H29N5
化学文摘社编号:
分子量:
423.55
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41121801
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
SMILES string
N#CC(CCCN1CCN(CC1)\N=C\c2cccnc2)(c3ccccc3)c4ccccc4
InChI
1S/C27H29N5/c28-23-27(25-10-3-1-4-11-25,26-12-5-2-6-13-26)14-8-16-31-17-19-32(20-18-31)30-22-24-9-7-15-29-21-24/h1-7,9-13,15,21-22H,8,14,16-20H2/b30-22+
InChI key
QFYKXKMYVYOUNJ-JBASAIQMSA-N
Application
SC-26196 has been used as an inhibitor of delta6 (Δ6) fatty acid desaturase:
- in mouse inner medullary collecting duct (IMCD3) and human (female) embryonic kidney (HEK) 293 cell culture as Dulbecco′s modified eagle′s medium (DMEM) component
- in hepatic HepG2 cells
- in glioblastoma cell lines to test its effect post-radiation treatments
Biochem/physiol Actions
Delta6-desaturase inhibitor
SC-26196 is a Delta6 fatty acid desaturase (Delta6D) inhibitor. It specifically inhibited Delta6D activity with an IC(50) value of 100 nM. The rate-limiting step in arachidonic acid synthesis is the desaturation of dietary linoleic acid by Delta6D. SC-26196 completely prevented this conversion of linoleic acid to arachidonic acid.
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable