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PZ0181

PD184352

Name: PD184352
Brand: SIGMA

≥98% (HPLC)

Synonym(s):

2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide, CI-1040

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₄ClF₂IN₂O₂

CAS Number:

212631-79-3

Molecular Weight:

478.66

NACRES:

NA.77

PubChem Substance ID:

329823755

UNSPSC Code:

51111800

MDL number:

MFCD02683961

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥30 mg/mL

storage temp.

room temp

SMILES string

Fc1ccc(C(=O)NOCC2CC2)c(Nc3ccc(I)cc3Cl)c1F

InChI

1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)

InChI key

GFMMXOIFOQCCGU-UHFFFAOYSA-N

Gene Information

human ... MAP2K1(5604), MAP2K2(5605)

Description

Biochem/physiol Actions

PD184352 (CI-1040) is a highly selective MEK (MKK1; MAPK kinase) inhibitor.

PD184352 (CI-1040) is a highly selective non-competitive inhibitor of MEK (MKK1; MAPK kinase) and the closely related MKK2. It has anti-cancer activity, suppresses the ERK pathway, and has been used along with other classes of inhibitors to establish embryonic stem cell lines.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.