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Merck
CN

PZ0187

Begacestat

≥98% (HPLC)

Synonym(s):

5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2- (trifluoromethyl)propyl] thiophene-2-sulfonamide, GSI-953

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About This Item

Empirical Formula (Hill Notation):
C9H8ClF6NO3S2
CAS Number:
769169-27-9
Molecular Weight:
391.74
NACRES:
NA.77
PubChem Substance ID:
329823761
UNSPSC Code:
51111800
MDL number:
MFCD18782675

Key Documents

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InChI

1S/C9H8ClF6NO3S2/c10-5-1-2-6(21-5)22(19,20)17-4(3-18)7(8(11,12)13)9(14,15)16/h1-2,4,7,17-18H,3H2/t4-/m1/s1

SMILES string

OC[C@@H](NS(=O)(=O)c1ccc(Cl)s1)C(C(F)(F)F)C(F)(F)F

InChI key

PSXOKXJMVRSARX-SCSAIBSYSA-N

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥15 mg/mL

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... APH1A(51107), APH1B(83464), NCSTN(23385), PSEN1(5663), PSEN2(5664), PSENEN(55851)

Biochem/physiol Actions

Begacestat (GSI-953) is a selective γ-secretase inhibitor that selectively inhibits cleavage of APP over Notch.
Begacestat is a potent APP-selective γ-secretase inhibitor (GSI) that is well-tolerated in mouse and dog.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000131909
0000043181
0000043183
016M4713V
061M4736V

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Dingding Mo et al.
Cells, 9(10) (2020-10-03)
Alzheimer's disease (AD) is an age-related detrimental dementia. Amyloid beta peptides (Aβ) play a crucial role in the pathology of AD. In familial AD, Aβ are generated from the full-length amyloid beta precursor protein (APP) via dysregulated proteolytic processing; however

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