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PZ0198

Prinomastat hydrochloride

≥95% (HPLC), MMP inhibitor, powder

Synonym(s):

(S)-2,2-Dimethyl-4-((p-(4-pyridyloxy)phenyl)sulfonyl)-3-thiomorpholinecarbohydroxamic acid hydrochloride, AG 3340 hydrochloride, AG-3340 hydrochloride, AG3340 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C18H21N3O5S2 · HCl
CAS Number:
192329-42-3
Molecular Weight:
459.97
UNSPSC Code:
12352200
PubChem Substance ID:
329823770
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
desiccated
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Product Name

Prinomastat hydrochloride, ≥95% (HPLC)

Quality Segment

100

assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 15 mg/mL (clear solution)

storage temp.

room temp

SMILES string

Cl.CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c2ccc(Oc3ccncc3)cc2

InChI

1S/C18H21N3O5S2.ClH/c1-18(2)16(17(22)20-23)21(11-12-27-18)28(24,25)15-5-3-13(4-6-15)26-14-7-9-19-10-8-14;/h3-10,16,23H,11-12H2,1-2H3,(H,20,22);1H/t16-;/m0./s1

InChI key

UQGWXXLNXBRNBU-NTISSMGPSA-N

General description

Prinomastat comprises hydroxamic acid group and chelates with zinc ion.PMID 25667046

Application

Prinomastat hydrochloride has been used as an antagonist for metalloproteinases (MMPs) in Crotalus atrox venom samplesPMID 12225776 and mouse embryo cultures.PMID 12508050 It may be used as a MMP-2 inhibitor in HepG2 cells.PMID 28883413

Biochem/physiol Actions

Prinomastat is a matrix metalloprotease (MMP) inhibitor with selectivity for MMPs 2, 3, 9, 13, and 14. Inhibition of these MMPs has been postulated to block tumor invasion and metastasis. It is extremely potent at MMP-3 and MMP-2 with IC50s, 30 pM & 50 pM, respectively.
Prinomastat is a matrix metalloprotease (MMP) inhibitor.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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