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Merck
CN

PZ0205

CE-178253 benzenesulfonate salt

≥98% (HPLC)

Synonym(s):

1-[7-(2-Chlorophenyl)-8-(4-chlorophenyl)-2-methylpyrazolo[1,5-a]-1,3,5-triazin-4-yl]-3-(ethylamino)-3-azetidinecarboxamide benzenesulfonate salt

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About This Item

Empirical Formula (Hill Notation):
C24H23Cl2N7O · C6H6O3S
CAS Number:
956246-95-0
Molecular Weight:
654.57
NACRES:
NA.77
PubChem Substance ID:
329823773
UNSPSC Code:
51111800
MDL number:
MFCD22666387

Key Documents

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InChI

1S/C24H23Cl2N7O.C6H6O3S/c1-3-28-24(22(27)34)12-32(13-24)23-30-14(2)29-21-19(15-8-10-16(25)11-9-15)20(31-33(21)23)17-6-4-5-7-18(17)26;7-10(8,9)6-4-2-1-3-5-6/h4-11,28H,3,12-13H2,1-2H3,(H2,27,34);1-5H,(H,7,8,9)

SMILES string

OS(=O)(=O)c1ccccc1.CCNC2(CN(C2)c3nc(C)nc4c(-c5ccc(Cl)cc5)c(nn34)-c6ccccc6Cl)C(N)=O

InChI key

PUVYOZFJBITEFT-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL (clear solution)

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

CE-178253 is an extremely potent and selective CB1 antagonist.
CE-178253 is an extremely potent and selective CB1 antagonist with sub-nanomolar potency. In binding assays, CE-178253 has a 0.33 nM Ki for human CB1, vs. a Ki of > 10 mM for human CB2.

Features and Benefits

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
082M4720V

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