PZ0213
PF-04418948
≥98% (HPLC)
Synonym(s):
1-(4-Fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C23H20FNO5
CAS Number:
Molecular Weight:
409.41
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
room temp
SMILES string
Fc1ccc(cc1)C(=O)N2CC(C2)(COc3cc4c(cc(cc4)OC)cc3)C(=O)O
InChI
1S/C23H20FNO5/c1-29-19-8-4-17-11-20(9-5-16(17)10-19)30-14-23(22(27)28)12-25(13-23)21(26)15-2-6-18(24)7-3-15/h2-11H,12-14H2,1H3,(H,27,28)
InChI key
LWJGMYMNSNVCEM-UHFFFAOYSA-N
Application
PF-04418948 has been used in TG (trigeminal ganglion) explant culture.
Biochem/physiol Actions
PF-04418948 represses the formation of colorectal tumor.
PF-04418948 is a PGE2 Receptor (EP2) specific antagonist (IC50 = 16 nM) with greater than 2000-fold selectivity over other EP subtypes. PF-04418948 inhibits EP2 activity in smooth muscle preps from human, dog and mouse.
PF-04418948 is a PGE2 Receptor (EP2) specific antagonist.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
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Glial interleukin-1β upregulates neuronal sodium channel 1.7 in trigeminal ganglion contributing to temporomandibular joint inflammatory hypernociception in rats.
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Journal of Neuroinflammation, 15(1), 117-117 (2018)
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Glomerular hyperfiltration is an important mechanism in the development of albuminuria. During hyperfiltration, podocytes are exposed to increased fluid flow shear stress (FFSS) in Bowman's space. Elevated Prostaglandin E2 (PGE2) synthesis and upregulated cyclooxygenase 2 (Cox2) are associated with podocyte
Global Trade Item Number
| SKU | GTIN |
|---|---|
| PZ0213-5MG | 04061832786155 |
| PZ0213-25MG | 04061832786148 |