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PZ0218

PF-03814735

≥98% (HPLC)

Synonym(s):

N-[2-[(1S,4R)-6-[[4-(Cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]-acetamide

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About This Item

Empirical Formula (Hill Notation):
C23H25F3N6O2
CAS Number:
942487-16-3
Molecular Weight:
474.48
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

FC(F)(F)c1c(nc(nc1)Nc3cc4c(cc3)[C@H]5N([C@@H]4CC5)C(=O)CNC(=O)C)NC2CCC2

InChI

1S/C23H25F3N6O2/c1-12(33)27-11-20(34)32-18-7-8-19(32)16-9-14(5-6-15(16)18)30-22-28-10-17(23(24,25)26)21(31-22)29-13-3-2-4-13/h5-6,9-10,13,18-19H,2-4,7-8,11H2,1H3,(H,27,33)(H2,28,29,30,31)/t18-,19+/m0/s1

InChI key

RYYNGWLOYLRZLK-RBUKOAKNSA-N

Biochem/physiol Actions

PF-03814735 is a potent inhibitor of Aurora kinase A and B (IC50 = 5 and 0.8 nM, respectively). PF-03814735 inhibits proliferation of tumor cells in culture and in xenograft tumor models. The compound PF-03814735 blocks phosphorylation of Aurora B and Histone H3, and leads to the formation of polyploid cells in culture (HCT116 and MDA-MB-231).
PF-03814735 is a potent inhibitor of Aurora kinase A and B.

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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