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Merck
CN

PZ0235

PF-04691502

≥98% (HPLC)

Synonym(s):

2-Amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxy-3-pyridinyl)-4-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one, PF-4691502, PF04691502

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About This Item

Empirical Formula (Hill Notation):
C22H27N5O4
CAS Number:
1013101-36-4
Molecular Weight:
425.48
UNSPSC Code:
12352200
PubChem Substance ID:
329823786
NACRES:
NA.77

Key Documents

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Product Name

PF-04691502, ≥98% (HPLC)

form

powder

color

, white to yellow to light brown

SMILES string

CC1=C(C(N([C@H]2CC[C@H](OCCO)CC2)C3=O)=NC(N)=N1)C=C3C4=CN=C(OC)C=C4

InChI

1S/C22H27N5O4/c1-13-17-11-18(14-3-8-19(30-2)24-12-14)21(29)27(20(17)26-22(23)25-13)15-4-6-16(7-5-15)31-10-9-28/h3,8,11-12,15-16,28H,4-7,9-10H2,1-2H3,(H2,23,25,26)/t15-,16-

InChI key

XDLYKKIQACFMJG-WKILWMFISA-N

assay

≥98% (HPLC)

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

room temp

Quality Level

100

Gene Information

human ... MTOR(2475), PIK3CA(5290), PIK3CB(5291), PIK3CD(5293), PIK3CG(5294), PIK3R1(5295), PIK3R2(5296), PIK3R3(8503), PIK3R5(23533)

Biochem/physiol Actions

PF-04691502 is a potent dual mTOR/PI3K inhibitor with Ki values of 1.6, 1.8, 1.9, 2.1 and 16 nM for human PI 3-K δ, α, β, γ, and mTOR, respectively, with no significant inhibitory activity at more than 80 other protein kinases, including PI 3-K downstream kinases, and MAPK family members. PF-04691502 showed antitumor activity in several non-small cell lung carcer (NSCLC) xenografts and ovarian cancer cell lines. PF-04691502 is currently in clinical trials.
PF-04691502 is a potent dual mTOR/PI3K inhibitor.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000129064
0000097427
0000044226
104M4729V

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