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Merck
CN

PZ0254

PF-06273340

≥98% (HPLC)

Synonym(s):

N-(5-{[2-Amino-7-(2-hydroxy-1 ,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5- yl]carbonyl}pyridin-3-yl)-2-(5-chloropyridin-2-yl)acetamide, N-[5-[[2-Amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl]-3-pyridinyl]-5-chloro-2-pyridineacetamide, PF 06273340, PF06273340

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About This Item

Empirical Formula (Hill Notation):
C23H22ClN7O3
CAS Number:
1402438-74-7
Molecular Weight:
479.92
UNSPSC Code:
51111800
PubChem Substance ID:
329823793
NACRES:
NA.77

Key Documents

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SMILES string

CC(CO)(C)N1C2=NC(N)=NC=C2C(C(C3=CN=CC(NC(CC4=CC=C(Cl)C=N4)=O)=C3)=O)=C1

InChI

1S/C23H22ClN7O3/c1-23(2,12-32)31-11-18(17-10-28-22(25)30-21(17)31)20(34)13-5-16(9-26-7-13)29-19(33)6-15-4-3-14(24)8-27-15/h3-5,7-11,32H,6,12H2,1-2H3,(H,29,33)(H2,25,28,30)

InChI key

BPIWZDNVMQQBQX-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

, white to yellow to brown

solubility

DMSO: 20 mg/mL, clear

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

PF-06273340 is a brain penetrant, orally available and potent tropomyosin-related kinase (Trk) inhibitor.
PF-06273340 is a brain penetrant, orally available and potent tropomyosin-related kinase (Trk) inhibitor. PF-06273340 is under development as a remedy acute and chronic pain.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000231277
0000231277
0000044865
0000044866
0000026641

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