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Merck
CN

PZ0274

PF-01247324

≥98% (HPLC)

Synonym(s):

6-Amino-5-(2,3,5-trichlorophenyl)pyridine-2-carboxylic acid methylamide, 6-Amino-N-methyl-5-(2,3,5-trichlorophenyl)-2-Pyridinecarboxamide, N-Methyl-6-amino-5-(2,3,5-trichlorophenyl)pyridine-2-carboxamide, PF 01247324, PF-1247324

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About This Item

Empirical Formula (Hill Notation):
C13H10Cl3N3O
CAS Number:
875051-72-2
Molecular Weight:
330.60
UNSPSC Code:
41121801
NACRES:
NA.77

Key Documents

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SMILES string

Clc1c(cc(cc1c2c(nc(cc2)C(=O)NC)N)Cl)Cl

InChI

1S/C13H10Cl3N3O/c1-18-13(20)10-3-2-7(12(17)19-10)8-4-6(14)5-9(15)11(8)16/h2-5H,1H3,(H2,17,19)(H,18,20)

InChI key

HPIUHDCRVYDAEJ-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

In humans, PF-01247324 [6-amino-5-(2, 3, 5-trichloro-phenyl)-pyridine-2-carboxylic acid methylamide] prevents native tetrodotoxin-resistant (TTX-R) currents in dorsal root ganglion (DRG) neurons.
PF-01247324 is an orally bioavailable, selective and potent NaV1.8 channel blocker that inhibits that exhibits analgesic efficacy in rodent behavioral models of pain.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000192433
0000192433
0000101004
0000101003
0000098865

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A novel selective and orally bioavailable Nav1. 8 channel blocker, PF?01247324, attenuates nociception and sensory neuron excitability.
Payne CE, et al.
British Journal of Pharmacology, 172(10), 2654-2670 (2015)

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