PZ0280
CP-456773 sodium salt
≥98% (HPLC), powder, IL-1β secretion inhibitor
Synonym(s):
CRID3, Cytokine release inhibitory drug 3, MCC950, N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt
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About This Item
Empirical Formula (Hill Notation):
C20H23N2NaO5S
CAS Number:
Molecular Weight:
426.46
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
Product Name
CP-456773 sodium salt, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 20 mg/mL, clear
storage temp.
room temp
SMILES string
CC(O)(C)C1=COC(S([N-]C(NC2=C(CCC3)C3=CC4=C2CCC4)=O)(=O)=O)=C1.[Na+]
InChI
1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1
InChI key
LFQQNXFKPNZRFT-UHFFFAOYSA-M
Application
CP-456773 sodium salt has been used :
- In in vivo experiments to study the neuroprotective action of ketogenic diet.
- To study the effect of inhibition of NLRP3 (nod-like receptor protein 3) inflammasome activity on tumor progression in mouse models.
- To study the cholesterol crystal-mediated IL-1b (interleukin-1b) response in placental explants.
Biochem/physiol Actions
CP-456773 is known to inhibit the release of other proinflammatory cytokines such as IL-1α and IL-18. It is also referred to as MCC950.
CP-456773 sodium salt (CRID3) was found to act as a cytokine release inhibitory drug and inhibitor of the NLRP3 inflammasome. CP-456773 sodium salt inhibits interleukin 1β (IL-1β) secretion and caspase 1 processing.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Efficacy and pharmacology of the NLRP3 inflammasome inhibitor CP-456,773 (CRID3) in murine models of dermal and pulmonary inflammation.
Primiano M J, et al.
Journal of Immunology, 197(6), 2421-2433 (2016)
Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma.
Chen L, et al.
Cellular and Molecular Life Sciences, 75(11), 2045-2058 (2018)
Haining Wang et al.
Life sciences, 227, 101-113 (2019-04-20)
NLRP3 inflammasome has been reported associated with some inflammatory and autoimmune diseases. We previously researches showed that interleukin-23 (IL-23) and interleukin-17 (IL-17) aggravates the ischaemic injury of the brain tissue. However, it is poorly understood whether the NLPR3 inflammasome was
Global Trade Item Number
| SKU | GTIN |
|---|---|
| PZ0280-25MG | 04061836687601 |
| PZ0280-5MG | 04061836687618 |